Synthesis of (E)-2,3´,4,5´-Tetramethoxy[2-11C]stilbene

Lutz Frank Schweiger, Stuart A P Craib, Andrew Welch, Timothy Andrew Davies Smith

Research output: Contribution to journalArticle

Abstract

In this paper, we describe the radiosynthesis of the compound (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene was carried out via C-11-methylation of (E)-2-(hydroxy)-3',4,5'-trimethoxystilbene by using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene was obtained with a radiochemical purity greater than 95% in a 20 +/- 2% decay-corrected radiochemical yield, based upon [C-11]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1. 9 +/- 0.6 GBq/mu mol at EOB.

Original languageEnglish
Pages (from-to)1206-1210
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume50
Issue number13
Early online date19 Sep 2007
DOIs
Publication statusPublished - Nov 2007

Keywords

  • 2,3',4,5'-tetramethoxy[2-C-11]stilbene
  • human cytochrome p4501b1
  • expression
  • aryl-hydrocarbon receptor
  • CYP1B1
  • PET
  • inhibitors
  • cancer
  • potent
  • tumors

Cite this

Synthesis of (E)-2,3´,4,5´-Tetramethoxy[2-11C]stilbene. / Schweiger, Lutz Frank; Craib, Stuart A P; Welch, Andrew; Smith, Timothy Andrew Davies.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 50, No. 13, 11.2007, p. 1206-1210.

Research output: Contribution to journalArticle

Schweiger, Lutz Frank ; Craib, Stuart A P ; Welch, Andrew ; Smith, Timothy Andrew Davies. / Synthesis of (E)-2,3´,4,5´-Tetramethoxy[2-11C]stilbene. In: Journal of Labelled Compounds and Radiopharmaceuticals. 2007 ; Vol. 50, No. 13. pp. 1206-1210.
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