In this paper, we describe the radiosynthesis of the compound (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene was carried out via C-11-methylation of (E)-2-(hydroxy)-3',4,5'-trimethoxystilbene by using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene was obtained with a radiochemical purity greater than 95% in a 20 +/- 2% decay-corrected radiochemical yield, based upon [C-11]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1. 9 +/- 0.6 GBq/mu mol at EOB.
|Number of pages||5|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Early online date||19 Sep 2007|
|Publication status||Published - Nov 2007|
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