We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modi. cation of P3, P1, and P2' and combination of SAR display a > 100-fold increase in potency with good cellular activity (IC50 = 0.15 mu M) relative to the previously reported compound 3. (C) 2008 Elsevier Ltd. All rights reserved.
- Alzheimer's disease
- cyclic urea