Abstract
The pentafluorosulphanyl group (SF5) is a highly stable chemical function which has been attracting a great deal of interest owing to its peculiar chemical, structural, physicochemical and biological properties. Progress in the area of SF5-compounds has been somewhat hindered by the lack of straightforward lab-scale synthetic methods for introducing the SF5-group into organic molecules. However, recent synthetic progress, the availability of some SF5-building blocks from commercial suppliers and the discovery of interesting properties of SF5-substituted molecules in materials science, biology and drug discovery are giving new momentum to research in this fascinating area of fluorine chemistry. Synthesis, reactivity and biological properties of SF5-substituted organic molecules are herein reviewed with an emphasis on the work published after year 2000.
Original language | English |
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Pages (from-to) | 57-93 |
Number of pages | 38 |
Journal | Journal of Fluorine Chemistry |
Volume | 143 |
Early online date | 11 Jul 2012 |
DOIs | |
Publication status | Published - Nov 2012 |
Bibliographical note
AcknowledgementsWe thank the European Commission for financial support (Industry Academia Partnerships and Pathways project “PET BRAIN”, Contract No 251482). S.A. thanks the Northern Research Partnership (www.northscotland-research.ac.uk/) and Pharmaness (www.pharmaness.it) for co-funding a PhD studentship.
Keywords
- pentafluorosulphanyl group
- review
- synthesis
- biological properties