Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Matteo Zanda, Stefano Altomonte

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Abstract

The pentafluorosulphanyl group (SF5) is a highly stable chemical function which has been attracting a great deal of interest owing to its peculiar chemical, structural, physicochemical and biological properties. Progress in the area of SF5-compounds has been somewhat hindered by the lack of straightforward lab-scale synthetic methods for introducing the SF5-group into organic molecules. However, recent synthetic progress, the availability of some SF5-building blocks from commercial suppliers and the discovery of interesting properties of SF5-substituted molecules in materials science, biology and drug discovery are giving new momentum to research in this fascinating area of fluorine chemistry. Synthesis, reactivity and biological properties of SF5-substituted organic molecules are herein reviewed with an emphasis on the work published after year 2000.
Original languageEnglish
Pages (from-to)57-93
Number of pages38
JournalJournal of Fluorine Chemistry
Volume143
Early online date11 Jul 2012
DOIs
Publication statusPublished - Nov 2012

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Keywords

  • pentafluorosulphanyl group
  • review
  • synthesis
  • biological properties

Cite this

Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules. / Zanda, Matteo; Altomonte, Stefano.

In: Journal of Fluorine Chemistry, Vol. 143, 11.2012, p. 57-93.

Research output: Contribution to journalArticle

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