Systematic review of the literature on the ophthalmological side effects of interferons

Yara Fragoso, Marina Sanchez, sahm Paggiaro, Roberta Mastomauro, Gabriela da Silva Jacondino, Heather M Wilson

Research output: Contribution to journalArticlepeer-review


Interferons alpha and beta has been used worldwide for a few decades, altering the natural history of several severe diseases including hepatitis C, cancer and immune-mediated conditions such as multiple sclerosis. The adverse events profile of interferons is well established, but only isolated reports of ophthalmological complication of interferon therapy have been published. The objective of this work was to carry out a systematic review of the literature on the subject, bringing to light the need for careful ophthalmological monitoring of patients undergoing interferon treatment.
Nearly 500 cases of ophthalmological complications related to interferon have been reported. The most frequent findings were soft exudates, hemorrhage and ischemia of the retina.
Original languageEnglish
JournalArquivos Brasileiros de Oftalmologia
Publication statusAccepted/In press - 2011


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