Abstract
Background: T helper 1 (Th1) lymphocytes produce interferon gamma (IFN gamma), favouring cell mediated immunity; Th2 cells secrete interleukin-4 (IL-4), favouring humoral immunity. Cytokines produced in sepsis may effect Th subset predominance and subsequent immune responses.
Methods: We measured Th subsets in ten patients with severe sepsis, seven APACHE II score-matched non-septic critically ill control patients, and ten healthy subjects.
Mononuclear leukocytes were isolated and Th subsets: identified by flow cytometry. Results: The median (range) Th1/Th2 ratio was 0.46 (0.2-2.5) in patients with sepsis, which was significantly lower than both non-septic controls (median 2.5 (0.2-5.9), p = 0.050) and healthy subjects (median 3.9 (1.2-10.8), p = 0.01).
Conclusions: In patients with sepsis, Th2 antibody mediated (humoral) immune responses predominate. This type of response may lead to fibroblast activation and ultimately immunosuppression. Modulation of Th cell subset predominance may present a novel therapeutic option in the treatment of severe sepsis.
| Original language | English |
|---|---|
| Pages (from-to) | 106-109 |
| Number of pages | 4 |
| Journal | Intensive Care Medicine |
| Volume | 25 |
| Publication status | Published - 1999 |
Keywords
- leukocytes
- T cells
- sepsis
- cytokines
- interleukin-4
- interferon gamma
- ENDOTOXIN
- IL-10
- TH1