Taking control: Hijacking of Rab GTPases by intracellular bacterial pathogens

Stefania Spano, Jorge E. Galán

Research output: Contribution to journalReview article

3 Citations (Scopus)
3 Downloads (Pure)

Abstract

Intracellular bacterial pathogens survive and replicate within specialized eukaryotic cell organelles. To establish their intracellular niches these pathogens have adopted sophisticated strategies to control intracellular membrane trafficking. Since Rab-family GTPases are critical regulators of endocytic and secretory membrane trafficking events, many intracellular pathogens have evolved specific mechanisms to modulate or hijack Rab GTPases dynamics and trafficking functions. One such strategy is the delivery of bacterial effectors through specialized machines to specifically target Rab GTPases. Some of these effectors functionally mimic host proteins that regulate the Rab GTP cycle, while others regulate Rabs proteins through their post-translation modifications or proteolysis. In this review, we examine how the localization and function of Rab-family GTPases are altered during infection with three well-studied intracellular bacterial pathogens, Mycobacterium tuberculosis, Salmonella enterica and Legionella pneumophila. We also discuss recent findings about specific mechanisms by which these intracellular pathogens target this protein family.
Original languageEnglish
Pages (from-to)182-191
Number of pages10
JournalSmall GTPases
Volume9
Issue number1-2
Early online date5 Jul 2017
DOIs
Publication statusPublished - 2018

Fingerprint

rab GTP-Binding Proteins
Pathogens
GTP Phosphohydrolases
Legionella pneumophila
Intracellular Membranes
Proteins
Salmonella enterica
Proteolysis
Eukaryotic Cells
Membranes
Guanosine Triphosphate
Mycobacterium tuberculosis
Salmonella
Organelles
Infection

Keywords

  • Intracellular membrane trafficking
  • intracellular pathogens
  • Legionella pneumophila
  • Mycobacterium tuberculosis
  • Rab GTPases
  • Salmonella enterica

Cite this

Taking control : Hijacking of Rab GTPases by intracellular bacterial pathogens. / Spano, Stefania; Galán, Jorge E.

In: Small GTPases, Vol. 9, No. 1-2, 2018, p. 182-191.

Research output: Contribution to journalReview article

Spano, Stefania ; Galán, Jorge E. / Taking control : Hijacking of Rab GTPases by intracellular bacterial pathogens. In: Small GTPases. 2018 ; Vol. 9, No. 1-2. pp. 182-191.
@article{cea0c0af4f7841b29f15b531f1bf3497,
title = "Taking control: Hijacking of Rab GTPases by intracellular bacterial pathogens",
abstract = "Intracellular bacterial pathogens survive and replicate within specialized eukaryotic cell organelles. To establish their intracellular niches these pathogens have adopted sophisticated strategies to control intracellular membrane trafficking. Since Rab-family GTPases are critical regulators of endocytic and secretory membrane trafficking events, many intracellular pathogens have evolved specific mechanisms to modulate or hijack Rab GTPases dynamics and trafficking functions. One such strategy is the delivery of bacterial effectors through specialized machines to specifically target Rab GTPases. Some of these effectors functionally mimic host proteins that regulate the Rab GTP cycle, while others regulate Rabs proteins through their post-translation modifications or proteolysis. In this review, we examine how the localization and function of Rab-family GTPases are altered during infection with three well-studied intracellular bacterial pathogens, Mycobacterium tuberculosis, Salmonella enterica and Legionella pneumophila. We also discuss recent findings about specific mechanisms by which these intracellular pathogens target this protein family.",
keywords = "Intracellular membrane trafficking, intracellular pathogens, Legionella pneumophila, Mycobacterium tuberculosis, Rab GTPases, Salmonella enterica",
author = "Stefania Spano and Gal{\'a}n, {Jorge E.}",
note = "Work in the Span{\`o} laboratory is supported by the Wellcome Trust (grant no. 109680/Z/15/Z), the Royal Society (grant no. RG150386), and the BBSRC (grant no. BB/N017854/1). Work in the Gal{\'a}n laboratory is supported by the National Institute of Allergy and Infectious Diseases (grants AI055472 and AI079022 to J.E.G.).",
year = "2018",
doi = "10.1080/21541248.2017.1336192",
language = "English",
volume = "9",
pages = "182--191",
journal = "Small GTPases",
issn = "2154-1248",
publisher = "Landes Bioscience",
number = "1-2",

}

TY - JOUR

T1 - Taking control

T2 - Hijacking of Rab GTPases by intracellular bacterial pathogens

AU - Spano, Stefania

AU - Galán, Jorge E.

N1 - Work in the Spanò laboratory is supported by the Wellcome Trust (grant no. 109680/Z/15/Z), the Royal Society (grant no. RG150386), and the BBSRC (grant no. BB/N017854/1). Work in the Galán laboratory is supported by the National Institute of Allergy and Infectious Diseases (grants AI055472 and AI079022 to J.E.G.).

PY - 2018

Y1 - 2018

N2 - Intracellular bacterial pathogens survive and replicate within specialized eukaryotic cell organelles. To establish their intracellular niches these pathogens have adopted sophisticated strategies to control intracellular membrane trafficking. Since Rab-family GTPases are critical regulators of endocytic and secretory membrane trafficking events, many intracellular pathogens have evolved specific mechanisms to modulate or hijack Rab GTPases dynamics and trafficking functions. One such strategy is the delivery of bacterial effectors through specialized machines to specifically target Rab GTPases. Some of these effectors functionally mimic host proteins that regulate the Rab GTP cycle, while others regulate Rabs proteins through their post-translation modifications or proteolysis. In this review, we examine how the localization and function of Rab-family GTPases are altered during infection with three well-studied intracellular bacterial pathogens, Mycobacterium tuberculosis, Salmonella enterica and Legionella pneumophila. We also discuss recent findings about specific mechanisms by which these intracellular pathogens target this protein family.

AB - Intracellular bacterial pathogens survive and replicate within specialized eukaryotic cell organelles. To establish their intracellular niches these pathogens have adopted sophisticated strategies to control intracellular membrane trafficking. Since Rab-family GTPases are critical regulators of endocytic and secretory membrane trafficking events, many intracellular pathogens have evolved specific mechanisms to modulate or hijack Rab GTPases dynamics and trafficking functions. One such strategy is the delivery of bacterial effectors through specialized machines to specifically target Rab GTPases. Some of these effectors functionally mimic host proteins that regulate the Rab GTP cycle, while others regulate Rabs proteins through their post-translation modifications or proteolysis. In this review, we examine how the localization and function of Rab-family GTPases are altered during infection with three well-studied intracellular bacterial pathogens, Mycobacterium tuberculosis, Salmonella enterica and Legionella pneumophila. We also discuss recent findings about specific mechanisms by which these intracellular pathogens target this protein family.

KW - Intracellular membrane trafficking

KW - intracellular pathogens

KW - Legionella pneumophila

KW - Mycobacterium tuberculosis

KW - Rab GTPases

KW - Salmonella enterica

U2 - 10.1080/21541248.2017.1336192

DO - 10.1080/21541248.2017.1336192

M3 - Review article

C2 - 28632996

VL - 9

SP - 182

EP - 191

JO - Small GTPases

JF - Small GTPases

SN - 2154-1248

IS - 1-2

ER -