Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?

Dana K Dawson; Christopher J Neil; Anke Henning; Donnie Cameron; Baljit Jagpal; Margaret Bruce; John Horowitz; Michael P Frenneaux

doi:10.1016/j.jcmg.2014.10.004

Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?

Dana K Dawson, Christopher J Neil, Anke Henning, Donnie Cameron, Baljit Jagpal, Margaret Bruce, John Horowitz, Michael P Frenneaux

Applied Medicine

Research output: Contribution to journal › Letter › peer-review

57 Citations (Scopus)

Abstract

Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.

Original language	English
Pages (from-to)	985-987
Number of pages	3
Journal	JACC. Cardiovascular Imaging
Volume	8
Issue number	8
Early online date	1 Nov 2014
DOIs	https://doi.org/10.1016/j.jcmg.2014.10.004
Publication status	Published - Aug 2015

Bibliographical note

Acknowledgments
The authors thank all their NHS consultant colleagues at Aberdeen Royal Infirmary for their help with prompt recruitment of these patients (Dr. Malcolm Metcalfe, Dr. Andrew Stewart, Dr. Andrew Hannah, Dr. Awsan Noman, Dr. Paul Broadhurst, Dr. Duncan Hogg, Dr. Deepak Garg) and to Dr. Caroline Scally, specialist cardiology trainee, for special effort with recruitment. Thanks also go to Ms. Bernice Kai Ng, medical student, for her initial work with cardiac spectroscopy in healthy volunteers and data entry.

Keywords

Tako-tsubo cardiomyopathy
Left ventricular systolic dysfunction

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10.1016/j.jcmg.2014.10.004

Dana Dawson
Person: Clinical Academic

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title = "Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?",

abstract = "Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.",

keywords = "Tako-tsubo cardiomyopathy, Left ventricular systolic dysfunction",

author = "Dawson, {Dana K} and Neil, {Christopher J} and Anke Henning and Donnie Cameron and Baljit Jagpal and Margaret Bruce and John Horowitz and Frenneaux, {Michael P}",

note = "Acknowledgments The authors thank all their NHS consultant colleagues at Aberdeen Royal Infirmary for their help with prompt recruitment of these patients (Dr. Malcolm Metcalfe, Dr. Andrew Stewart, Dr. Andrew Hannah, Dr. Awsan Noman, Dr. Paul Broadhurst, Dr. Duncan Hogg, Dr. Deepak Garg) and to Dr. Caroline Scally, specialist cardiology trainee, for special effort with recruitment. Thanks also go to Ms. Bernice Kai Ng, medical student, for her initial work with cardiac spectroscopy in healthy volunteers and data entry.",

year = "2015",

month = aug,

doi = "10.1016/j.jcmg.2014.10.004",

language = "English",

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journal = "JACC. Cardiovascular Imaging",

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T2 - A Heart Stressed Out of Energy?

AU - Dawson, Dana K

AU - Neil, Christopher J

AU - Henning, Anke

AU - Cameron, Donnie

AU - Jagpal, Baljit

AU - Bruce, Margaret

AU - Horowitz, John

AU - Frenneaux, Michael P

N1 - Acknowledgments The authors thank all their NHS consultant colleagues at Aberdeen Royal Infirmary for their help with prompt recruitment of these patients (Dr. Malcolm Metcalfe, Dr. Andrew Stewart, Dr. Andrew Hannah, Dr. Awsan Noman, Dr. Paul Broadhurst, Dr. Duncan Hogg, Dr. Deepak Garg) and to Dr. Caroline Scally, specialist cardiology trainee, for special effort with recruitment. Thanks also go to Ms. Bernice Kai Ng, medical student, for her initial work with cardiac spectroscopy in healthy volunteers and data entry.

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N2 - Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.

AB - Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.

KW - Tako-tsubo cardiomyopathy

KW - Left ventricular systolic dysfunction

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DO - 10.1016/j.jcmg.2014.10.004

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JO - JACC. Cardiovascular Imaging

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ER -

Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?

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Keywords

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