Tako-Tsubo Cardiomyopathy

A Heart Stressed Out of Energy?

Dana K Dawson, Christopher J Neil, Anke Henning, Donnie Cameron, Baljit Jagpal, Margaret Bruce, John Horowitz, Michael P Frenneaux

Research output: Contribution to journalLetter

27 Citations (Scopus)

Abstract

Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.
Original languageEnglish
Pages (from-to)985-987
Number of pages3
JournalJACC. Cardiovascular Imaging
Volume8
Issue number8
Early online date1 Nov 2014
DOIs
Publication statusPublished - Aug 2015

Fingerprint

Takotsubo Cardiomyopathy
Left Ventricular Dysfunction
Gadolinium
Muscle Cells
Magnetic Resonance Spectroscopy
Therapeutics

Keywords

  • Tako-tsubo cardiomyopathy
  • Left ventricular systolic dysfunction

Cite this

Tako-Tsubo Cardiomyopathy : A Heart Stressed Out of Energy? / Dawson, Dana K; Neil, Christopher J; Henning, Anke; Cameron, Donnie; Jagpal, Baljit; Bruce, Margaret; Horowitz, John; Frenneaux, Michael P.

In: JACC. Cardiovascular Imaging, Vol. 8, No. 8, 08.2015, p. 985-987.

Research output: Contribution to journalLetter

Dawson, DK, Neil, CJ, Henning, A, Cameron, D, Jagpal, B, Bruce, M, Horowitz, J & Frenneaux, MP 2015, 'Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?', JACC. Cardiovascular Imaging, vol. 8, no. 8, pp. 985-987. https://doi.org/10.1016/j.jcmg.2014.10.004
Dawson, Dana K ; Neil, Christopher J ; Henning, Anke ; Cameron, Donnie ; Jagpal, Baljit ; Bruce, Margaret ; Horowitz, John ; Frenneaux, Michael P. / Tako-Tsubo Cardiomyopathy : A Heart Stressed Out of Energy?. In: JACC. Cardiovascular Imaging. 2015 ; Vol. 8, No. 8. pp. 985-987.
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abstract = "Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.",
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note = "Acknowledgments The authors thank all their NHS consultant colleagues at Aberdeen Royal Infirmary for their help with prompt recruitment of these patients (Dr. Malcolm Metcalfe, Dr. Andrew Stewart, Dr. Andrew Hannah, Dr. Awsan Noman, Dr. Paul Broadhurst, Dr. Duncan Hogg, Dr. Deepak Garg) and to Dr. Caroline Scally, specialist cardiology trainee, for special effort with recruitment. Thanks also go to Ms. Bernice Kai Ng, medical student, for her initial work with cardiac spectroscopy in healthy volunteers and data entry.",
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AU - Cameron, Donnie

AU - Jagpal, Baljit

AU - Bruce, Margaret

AU - Horowitz, John

AU - Frenneaux, Michael P

N1 - Acknowledgments The authors thank all their NHS consultant colleagues at Aberdeen Royal Infirmary for their help with prompt recruitment of these patients (Dr. Malcolm Metcalfe, Dr. Andrew Stewart, Dr. Andrew Hannah, Dr. Awsan Noman, Dr. Paul Broadhurst, Dr. Duncan Hogg, Dr. Deepak Garg) and to Dr. Caroline Scally, specialist cardiology trainee, for special effort with recruitment. Thanks also go to Ms. Bernice Kai Ng, medical student, for her initial work with cardiac spectroscopy in healthy volunteers and data entry.

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N2 - Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.

AB - Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.

KW - Tako-tsubo cardiomyopathy

KW - Left ventricular systolic dysfunction

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DO - 10.1016/j.jcmg.2014.10.004

M3 - Letter

VL - 8

SP - 985

EP - 987

JO - JACC. Cardiovascular Imaging

JF - JACC. Cardiovascular Imaging

SN - 1936-878X

IS - 8

ER -