Targeting TRP ion channels for itch relief

Xuming Zhang

Research output: Contribution to journalLiterature review

15 Citations (Scopus)
14 Downloads (Pure)

Abstract

Acute itch (pruritus) is unpleasant and acts as an alerting mechanism for removing irritants. However, severe chronic itch is debilitating and impairs the quality of life. Rapid progress has been made in recent years in our understanding of the fundamental neurobiology of itch. Notably, several temperature-sensitive transient receptor potential (thermo-TRP) ion channels have emerged as critical players in many types of itch, in addition to pain. They serve as markers that define the itch neural pathway. Thermo-TRP ion channels are thus becoming attractive targets for developing effective anti-pruritic therapies.
Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume388
Issue number4
Early online date25 Nov 2014
DOIs
Publication statusPublished - Apr 2015

Fingerprint

Ion Channels
Neural Pathways
Neurobiology
Irritants
Pruritus
Quality of Life
Pain
Temperature
Therapeutics

Keywords

  • TRP ion channels
  • itch
  • pain
  • somatosensory transduction

Cite this

Targeting TRP ion channels for itch relief. / Zhang, Xuming.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 388, No. 4, 04.2015, p. 389-399.

Research output: Contribution to journalLiterature review

Zhang, Xuming. / Targeting TRP ion channels for itch relief. In: Naunyn-Schmiedeberg's Archives of Pharmacology. 2015 ; Vol. 388, No. 4. pp. 389-399.
@article{619f33795350444aa7e5ae51c0b686e4,
title = "Targeting TRP ion channels for itch relief",
abstract = "Acute itch (pruritus) is unpleasant and acts as an alerting mechanism for removing irritants. However, severe chronic itch is debilitating and impairs the quality of life. Rapid progress has been made in recent years in our understanding of the fundamental neurobiology of itch. Notably, several temperature-sensitive transient receptor potential (thermo-TRP) ion channels have emerged as critical players in many types of itch, in addition to pain. They serve as markers that define the itch neural pathway. Thermo-TRP ion channels are thus becoming attractive targets for developing effective anti-pruritic therapies.",
keywords = "TRP ion channels, itch, pain, somatosensory transduction",
author = "Xuming Zhang",
year = "2015",
month = "4",
doi = "10.1007/s00210-014-1068-z",
language = "English",
volume = "388",
pages = "389--399",
journal = "Naunyn-Schmiedeberg's Archives of Pharmacology",
issn = "0028-1298",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Targeting TRP ion channels for itch relief

AU - Zhang, Xuming

PY - 2015/4

Y1 - 2015/4

N2 - Acute itch (pruritus) is unpleasant and acts as an alerting mechanism for removing irritants. However, severe chronic itch is debilitating and impairs the quality of life. Rapid progress has been made in recent years in our understanding of the fundamental neurobiology of itch. Notably, several temperature-sensitive transient receptor potential (thermo-TRP) ion channels have emerged as critical players in many types of itch, in addition to pain. They serve as markers that define the itch neural pathway. Thermo-TRP ion channels are thus becoming attractive targets for developing effective anti-pruritic therapies.

AB - Acute itch (pruritus) is unpleasant and acts as an alerting mechanism for removing irritants. However, severe chronic itch is debilitating and impairs the quality of life. Rapid progress has been made in recent years in our understanding of the fundamental neurobiology of itch. Notably, several temperature-sensitive transient receptor potential (thermo-TRP) ion channels have emerged as critical players in many types of itch, in addition to pain. They serve as markers that define the itch neural pathway. Thermo-TRP ion channels are thus becoming attractive targets for developing effective anti-pruritic therapies.

KW - TRP ion channels

KW - itch

KW - pain

KW - somatosensory transduction

U2 - 10.1007/s00210-014-1068-z

DO - 10.1007/s00210-014-1068-z

M3 - Literature review

VL - 388

SP - 389

EP - 399

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

SN - 0028-1298

IS - 4

ER -