TY - CHAP
T1 - Techniques and Applications of Field-cycling Magnetic Resonance in Medicine
AU - Lurie, David J.
AU - Ross, P. James
AU - Broche, Lionel M.
PY - 2019
Y1 - 2019
N2 - Fast field cycling (FFC) offers a unique window on molecular dynamics for in vivo applications, thanks to its ability to measure the NMR dispersion profile. This chapter summarises the different technologies that have been developed to exploit FFC-MRI for biomedical applications since the first attempts around 1990, using a range of technology that has been developed to investigate the rich source of information provided by T1 dispersion. The chapter also discusses how FFC technologies based on resistive coils present some important limitations, including in the design of pulse sequences or in the quality of the data. In addition to reviewing important technologies and methods from a number of techniques in various laboratories, including Overhauser imaging, pre-polarised MRI and delta relaxation-enhanced MRI, we present some of the new challenges that human-sample FFC brings to magnetic resonance imaging (MRI) through illustrations from the recently completed resistive 0.2 T FFC-MRI system developed in the University of Aberdeen FFC laboratory. Finally, this chapter presents some of the promising results from medical studies on cancer, muscle damage and osteoarthritis, illustrating the possibilities offered by FFC-MRI in the search for entirely new biomarkers that might be used to improve the diagnosis and monitoring of disease in the future.
AB - Fast field cycling (FFC) offers a unique window on molecular dynamics for in vivo applications, thanks to its ability to measure the NMR dispersion profile. This chapter summarises the different technologies that have been developed to exploit FFC-MRI for biomedical applications since the first attempts around 1990, using a range of technology that has been developed to investigate the rich source of information provided by T1 dispersion. The chapter also discusses how FFC technologies based on resistive coils present some important limitations, including in the design of pulse sequences or in the quality of the data. In addition to reviewing important technologies and methods from a number of techniques in various laboratories, including Overhauser imaging, pre-polarised MRI and delta relaxation-enhanced MRI, we present some of the new challenges that human-sample FFC brings to magnetic resonance imaging (MRI) through illustrations from the recently completed resistive 0.2 T FFC-MRI system developed in the University of Aberdeen FFC laboratory. Finally, this chapter presents some of the promising results from medical studies on cancer, muscle damage and osteoarthritis, illustrating the possibilities offered by FFC-MRI in the search for entirely new biomarkers that might be used to improve the diagnosis and monitoring of disease in the future.
UR - http://www.scopus.com/inward/record.url?scp=85056659317&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/chapter-14-techniques-applications-fieldcycling-magnetic-resonance-medicine
UR - https://pubs.rsc.org/en/Content/Chapter/9781788012966-00358/978-1-78801-296-6
U2 - 10.1039/9781788012966-00358
DO - 10.1039/9781788012966-00358
M3 - Chapter (peer-reviewed)
AN - SCOPUS:85056659317
SN - 978-1-78801-154-9
T3 - New Developments in NMR
SP - 358
EP - 384
BT - Field-cycling NMR Relaxometry
A2 - Kimmich, Rainer
PB - Royal Society of Chemistry
ER -