Teleost fish interferons and their role in immunity

Research output: Contribution to journalLiterature review

211 Citations (Scopus)

Abstract

Interferons (IFNs) are the hallmark of the vertebrate antiviral system. Two of the three IFN families identified in higher vertebrates are now known to be important for antiviral defence in teleost fish. Based on the cysteine patterns, the fish type I IFN family can be divided into two subfamilies, which possibly interact with distinct receptors for signalling. The fish type II IFN family consists of two members. IFN-gamma with similar functions to mammalian IFN-gamma and a teleost specific IFN-gamma related (IFN-gamma rel) molecule whose functions are not fully elucidated. These two type II IFNs also appear to bind to distinct receptors to exert their functions. It has become clear that fish IFN responses are mediated by the host pattern recognition receptors and an array of transcription factors including the IFN regulatory factors, the Jak/Stat proteins and the suppressor of cytokine signalling (SOCS) molecules. (C) 2011 Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)1376-1387
Number of pages12
JournalDevelopmental and Comparative Immunology
Volume35
Issue number12
Early online date14 Jul 2011
DOIs
Publication statusPublished - Dec 2011

Keywords

  • interferon
  • interferon receptor
  • teleost fish
  • antiviral defence
  • evolution
  • trout oncorhynchus-mykiss
  • salmon salmo-salar
  • zebrafish danio-rerio
  • carassius-auratus L.
  • carp cyprinus-carpio
  • toll-like receptor-3
  • regulatory factor-I
  • double-stranded-RNA
  • NF-kappa-B
  • rainbow-trout

Cite this

Teleost fish interferons and their role in immunity. / Zou, Jun; Secombes, Christopher J.

In: Developmental and Comparative Immunology, Vol. 35, No. 12, 12.2011, p. 1376-1387.

Research output: Contribution to journalLiterature review

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AU - Secombes, Christopher J.

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KW - interferon

KW - interferon receptor

KW - teleost fish

KW - antiviral defence

KW - evolution

KW - trout oncorhynchus-mykiss

KW - salmon salmo-salar

KW - zebrafish danio-rerio

KW - carassius-auratus L.

KW - carp cyprinus-carpio

KW - toll-like receptor-3

KW - regulatory factor-I

KW - double-stranded-RNA

KW - NF-kappa-B

KW - rainbow-trout

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DO - 10.1016/j.dci.2011.07.001

M3 - Literature review

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JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

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