TY - JOUR
T1 - Temporospatial coordination of meiotic DNA replication and recombination via DDK recruitment to replisomes
AU - Murakami, H.
AU - Keeney, S.
N1 - Erratum: Hajime Murakami, Scott Keeney,Temporospatial Coordination of Meiotic DNA Replication and Recombination via DDK Recruitment to Replisomes Cell,
Volume 159, Issue 3, 2014, Pages 697-698, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2014.10.021
Refers to
Hajime Murakami, Scott Keeney Temporospatial Coordination of Meiotic DNA Replication and Recombination via DDK Recruitment to Replisomes Cell, Volume 158, Issue 4, 14 August 2014, Pages 861-873
PY - 2014/8/14
Y1 - 2014/8/14
N2 - It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 physically associate with the Dbf4-dependent Cdc7 kinase (DDK) and recruit it to the replisome, where it phosphorylates the DSB-promoting factor Mer2 in the wake of the replication fork, synchronizing replication with an early prerequisite for DSB formation. Recruiting regulatory kinases to replisomes may be a general mechanism to ensure spatial and temporal coordination of replication with other chromosomal processes.
AB - It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 physically associate with the Dbf4-dependent Cdc7 kinase (DDK) and recruit it to the replisome, where it phosphorylates the DSB-promoting factor Mer2 in the wake of the replication fork, synchronizing replication with an early prerequisite for DSB formation. Recruiting regulatory kinases to replisomes may be a general mechanism to ensure spatial and temporal coordination of replication with other chromosomal processes.
UR - https://synapse.mskcc.org//synapse/works/65008
UR - https://www.sciencedirect.com/science/article/pii/S0092867414013099
U2 - 10.1016/j.cell.2014.06.028
DO - 10.1016/j.cell.2014.06.028
M3 - Article
C2 - 25126790
VL - 158
SP - 861
EP - 873
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -