Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese

W Q Liu, N F Gu, G Y Feng, S Li, S C Bai, J G Zhang, T Shen, H Xue, G Breen, D St Clair, L He

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Abstract

The serotonin transporter gene (SERT) plays an important role in the serotonin uptake into neurons, Recently, several polymorphisms including a variable-number-tandem-repeat (VNTR) in the second intron and an insertion/deletion polymorphism (5-HTT linked polymorphic region, 5-HTTLPR) were identified and reported to be associated with a variety of mental illnesses, including major depression, bipolar disorder, anxiety-related traits, and autism, in our study, we performed an association study between the SERT VNTR polymorphism and schizophrenia (n = 260), bipolar disorder (n = 137), and unipolar depression (n = 33) in the Han Chinese. A large group of ethnically matched control individuals (n = 362) were also genotyped. Allele 12 of the VNTR polymorphism was associated with schizophrenia (P = 0.007) and unipolar depression (P = 0.011). Bipolar disorder was not associated with the VNTR (P = 0.93). Thus, we conclude that the SERT VNTR polymorphism may be a risk factor for both schizophrenia and unipolar depression, but not for bipolar disorder, in the Halt Chinese. Pharmacogenetics 9:491-495 (C) 1999 Lippincott Williams & Wilkins.

Original languageEnglish
Pages (from-to)491-495
Number of pages5
JournalPharmacogenetics
Volume9
Publication statusPublished - 1999

Keywords

  • bipolar disorder
  • Han-Chinese
  • schizophrenia
  • serotonin transporter
  • VNTR
  • unipolar depression
  • GENE POLYMORPHISMS
  • TANDEM REPEAT
  • 5-HTT GENE
  • SUSCEPTIBILITY

Cite this

Liu, W. Q., Gu, N. F., Feng, G. Y., Li, S., Bai, S. C., Zhang, J. G., ... He, L. (1999). Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics, 9, 491-495.

Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. / Liu, W Q ; Gu, N F ; Feng, G Y ; Li, S ; Bai, S C ; Zhang, J G ; Shen, T ; Xue, H ; Breen, G ; St Clair, D ; He, L .

In: Pharmacogenetics, Vol. 9, 1999, p. 491-495.

Research output: Contribution to journalArticle

Liu, WQ, Gu, NF, Feng, GY, Li, S, Bai, SC, Zhang, JG, Shen, T, Xue, H, Breen, G, St Clair, D & He, L 1999, 'Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese', Pharmacogenetics, vol. 9, pp. 491-495.
Liu, W Q ; Gu, N F ; Feng, G Y ; Li, S ; Bai, S C ; Zhang, J G ; Shen, T ; Xue, H ; Breen, G ; St Clair, D ; He, L . / Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. In: Pharmacogenetics. 1999 ; Vol. 9. pp. 491-495.
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AB - The serotonin transporter gene (SERT) plays an important role in the serotonin uptake into neurons, Recently, several polymorphisms including a variable-number-tandem-repeat (VNTR) in the second intron and an insertion/deletion polymorphism (5-HTT linked polymorphic region, 5-HTTLPR) were identified and reported to be associated with a variety of mental illnesses, including major depression, bipolar disorder, anxiety-related traits, and autism, in our study, we performed an association study between the SERT VNTR polymorphism and schizophrenia (n = 260), bipolar disorder (n = 137), and unipolar depression (n = 33) in the Han Chinese. A large group of ethnically matched control individuals (n = 362) were also genotyped. Allele 12 of the VNTR polymorphism was associated with schizophrenia (P = 0.007) and unipolar depression (P = 0.011). Bipolar disorder was not associated with the VNTR (P = 0.93). Thus, we conclude that the SERT VNTR polymorphism may be a risk factor for both schizophrenia and unipolar depression, but not for bipolar disorder, in the Halt Chinese. Pharmacogenetics 9:491-495 (C) 1999 Lippincott Williams & Wilkins.

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