Testing for thrombophilia: an evidence-based approach

L. Merriman, Michael Greaves

Research output: Contribution to journalLiterature review

36 Citations (Scopus)

Abstract

Thrombophilia is a disorder of haemostasis in which there is a tendency for the occurrence of thrombosis. This tendency can be inherited or acquired. This review outlines common acquired and inherited thrombophilic conditions and discusses indications for testing. It is concluded that testing for acquired thrombophilic conditions should be considered in all cases of venous thrombosis, whereas testing for inherited thrombophilic conditions is unlikely to be helpful. If testing for inherited thrombophilia is to be carried out, the benefits, pitfalls and unwanted consequences of such testing should be taken into account.

Original languageEnglish
Pages (from-to)699-704
Number of pages6
JournalPostgraduate Medical Journal
Volume82
DOIs
Publication statusPublished - 2006

Keywords

  • Factor V Leiden
  • recurrent venous thromboembolism
  • deep-vein thrombosis
  • replacement therapy
  • prospective cohort
  • family members
  • risk factors
  • heterozgous carriers
  • oral contraceptives
  • protein C

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