TGF-beta 3 exists in bony fish

K J Laing, L Pilstrom, C Cunningham, C J Secombes

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A partial nucleotide sequence of transforming growth factor-beta 3 (TGF-beta 3) has been isolated from the Siberian sturgeon (Acipenser baeri), rainbow trout (Oncorhynchus mykiss) and European eel (Anguilla anguilla), confirming a ubiquitous presence in the ray-finned (Actinopterygian) bony fish. The bony fish TGF-beta 3 is highly conserved, with some 83-84% nucleotide identity (coding region) and 90-95% predicted amino acid identity to known homeotherm TGF-beta 3's. Far lower homologies are apparent with other known TGF-P isoforms in fish (e.g. 64-66% and 81-82% amino acid identity to trout TGF beta 1/5 and carp TGF-beta 2 respectively). Phylogenetic tree analysis showed that the fish TGF-beta 3's clustered with the known homeotherm TGF-beta 3's. The relatively tight clustering of TGF-beta 1, TGF-beta 2 and TGF-beta 3 was in contrast to the TGF-beta 5's, which are clearly a more heterogenous group. (C) 1999 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalVeterinary Immunology and Immunopathology
Volume72
Publication statusPublished - 1999

Keywords

  • bony fish
  • teleosts
  • chondrosteans
  • TGF-beta 3
  • partial gene
  • TRANSFORMING GROWTH FACTOR-BETA-5
  • TROUT ONCORHYNCHUS-MYKISS
  • XENOPUS-LAEVIS
  • TGF-BETA
  • SEQUENCE
  • GENE
  • EXPRESSION
  • CDNA

Cite this

Laing, K. J., Pilstrom, L., Cunningham, C., & Secombes, C. J. (1999). TGF-beta 3 exists in bony fish. Veterinary Immunology and Immunopathology, 72, 45-53.

TGF-beta 3 exists in bony fish. / Laing, K J ; Pilstrom, L ; Cunningham, C ; Secombes, C J .

In: Veterinary Immunology and Immunopathology, Vol. 72, 1999, p. 45-53.

Research output: Contribution to journalArticle

Laing, KJ, Pilstrom, L, Cunningham, C & Secombes, CJ 1999, 'TGF-beta 3 exists in bony fish', Veterinary Immunology and Immunopathology, vol. 72, pp. 45-53.
Laing, K J ; Pilstrom, L ; Cunningham, C ; Secombes, C J . / TGF-beta 3 exists in bony fish. In: Veterinary Immunology and Immunopathology. 1999 ; Vol. 72. pp. 45-53.
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AU - Laing, K J

AU - Pilstrom, L

AU - Cunningham, C

AU - Secombes, C J

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N2 - A partial nucleotide sequence of transforming growth factor-beta 3 (TGF-beta 3) has been isolated from the Siberian sturgeon (Acipenser baeri), rainbow trout (Oncorhynchus mykiss) and European eel (Anguilla anguilla), confirming a ubiquitous presence in the ray-finned (Actinopterygian) bony fish. The bony fish TGF-beta 3 is highly conserved, with some 83-84% nucleotide identity (coding region) and 90-95% predicted amino acid identity to known homeotherm TGF-beta 3's. Far lower homologies are apparent with other known TGF-P isoforms in fish (e.g. 64-66% and 81-82% amino acid identity to trout TGF beta 1/5 and carp TGF-beta 2 respectively). Phylogenetic tree analysis showed that the fish TGF-beta 3's clustered with the known homeotherm TGF-beta 3's. The relatively tight clustering of TGF-beta 1, TGF-beta 2 and TGF-beta 3 was in contrast to the TGF-beta 5's, which are clearly a more heterogenous group. (C) 1999 Elsevier Science B.V. All rights reserved.

AB - A partial nucleotide sequence of transforming growth factor-beta 3 (TGF-beta 3) has been isolated from the Siberian sturgeon (Acipenser baeri), rainbow trout (Oncorhynchus mykiss) and European eel (Anguilla anguilla), confirming a ubiquitous presence in the ray-finned (Actinopterygian) bony fish. The bony fish TGF-beta 3 is highly conserved, with some 83-84% nucleotide identity (coding region) and 90-95% predicted amino acid identity to known homeotherm TGF-beta 3's. Far lower homologies are apparent with other known TGF-P isoforms in fish (e.g. 64-66% and 81-82% amino acid identity to trout TGF beta 1/5 and carp TGF-beta 2 respectively). Phylogenetic tree analysis showed that the fish TGF-beta 3's clustered with the known homeotherm TGF-beta 3's. The relatively tight clustering of TGF-beta 1, TGF-beta 2 and TGF-beta 3 was in contrast to the TGF-beta 5's, which are clearly a more heterogenous group. (C) 1999 Elsevier Science B.V. All rights reserved.

KW - bony fish

KW - teleosts

KW - chondrosteans

KW - TGF-beta 3

KW - partial gene

KW - TRANSFORMING GROWTH FACTOR-BETA-5

KW - TROUT ONCORHYNCHUS-MYKISS

KW - XENOPUS-LAEVIS

KW - TGF-BETA

KW - SEQUENCE

KW - GENE

KW - EXPRESSION

KW - CDNA

M3 - Article

VL - 72

SP - 45

EP - 53

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

SN - 0165-2427

ER -