The 2022 British Society for Rheumatology guideline for the treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs

Laura Tucker; Alexander Allen; David Chandler; Coziana Ciurtin; Andrew Dick; Amy Foulkes; Nicola Gullick; Philip Helliwell; Deepak Jadon; Gareth Jones; Stuart Kyle; Vishnu Madhok; Neil McHugh; Andrew Parkinson; Tim Raine; Stefan Siebert; Catherine Smith; William Tillett; Laura C. Coates

doi:10.1093/rheumatology/keac295

The 2022 British Society for Rheumatology guideline for the treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs

Laura Tucker, Alexander Allen, David Chandler, Coziana Ciurtin, Andrew Dick, Amy Foulkes, Nicola Gullick, Philip Helliwell, Deepak Jadon, Gareth Jones, Stuart Kyle, Vishnu Madhok, Neil McHugh, Andrew Parkinson, Tim Raine, Stefan Siebert, Catherine Smith, William Tillett, Laura C. Coates^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

PsA is a chronic, inflammatory, musculoskeletal disease affecting approximately one quarter of people with the skin condition psoriasis [1, 2]. PsA is a highly heterogeneous disease, encompassing diverse musculoskeletal manifestations or ‘domains’ resulting from disease activity in different tissues. These include peripheral arthritis, spondylitis (axial inflammation), dactylitis (inflammation of the whole digit) and enthesitis (inflammation where a tendon, ligament or joint capsule insert to the bone). Unlike RA, there is a significant variability in clinical presentation of PsA. Individuals with PsA may have different domains involved and drugs have different levels of effectiveness on each domain. It is therefore essential that clinical guidelines for the treatment selection in PsA include disease phenotype and differential effect of medication.

Original language	English
Pages (from-to)	e255-e266
Number of pages	12
Journal	Rheumatology (Oxford, England)
Volume	61
Issue number	9
Early online date	31 May 2022
DOIs	https://doi.org/10.1093/rheumatology/keac295
Publication status	Published - 1 Sept 2022

Bibliographical note

We gratefully acknowledge the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and the members of their Treatment Recommendations working group who shared extracted data on treatment RCTs for this project.

Funding: No specific funding was received from any bodies in the public, commercial or not-for-profit sectors to carry out the work described in this manuscript. Expenses for travel were paid by the British Society for Rheumatology.

Data Availability Statement

All relevant data produced during the guideline development process are presented in this manuscript or in the accompanying supplementary material.

Keywords

biologics
dactylitis
enthesitis
guideline
management
PsA
psoriasis
recommendations
targeted synthetic DMARDs
treatment

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Tucker, L., Allen, A., Chandler, D., Ciurtin, C., Dick, A., Foulkes, A., Gullick, N., Helliwell, P., Jadon, D., Jones, G., Kyle, S., Madhok, V., McHugh, N., Parkinson, A., Raine, T., Siebert, S., Smith, C., Tillett, W., & Coates, L. C. (2022). The 2022 British Society for Rheumatology guideline for the treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs. Rheumatology (Oxford, England), 61(9), e255-e266. https://doi.org/10.1093/rheumatology/keac295

Tucker, L, Allen, A, Chandler, D, Ciurtin, C, Dick, A, Foulkes, A, Gullick, N, Helliwell, P, Jadon, D, Jones, G, Kyle, S, Madhok, V, McHugh, N, Parkinson, A, Raine, T, Siebert, S, Smith, C, Tillett, W & Coates, LC 2022, 'The 2022 British Society for Rheumatology guideline for the treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs', Rheumatology (Oxford, England), vol. 61, no. 9, pp. e255-e266. https://doi.org/10.1093/rheumatology/keac295

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abstract = "PsA is a chronic, inflammatory, musculoskeletal disease affecting approximately one quarter of people with the skin condition psoriasis [1, 2]. PsA is a highly heterogeneous disease, encompassing diverse musculoskeletal manifestations or {\textquoteleft}domains{\textquoteright} resulting from disease activity in different tissues. These include peripheral arthritis, spondylitis (axial inflammation), dactylitis (inflammation of the whole digit) and enthesitis (inflammation where a tendon, ligament or joint capsule insert to the bone). Unlike RA, there is a significant variability in clinical presentation of PsA. Individuals with PsA may have different domains involved and drugs have different levels of effectiveness on each domain. It is therefore essential that clinical guidelines for the treatment selection in PsA include disease phenotype and differential effect of medication.",

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The 2022 British Society for Rheumatology guideline for the treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs

Abstract

Bibliographical note

Data Availability Statement

Keywords

Access to Document

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