The accuracy of single serum progesterone measurement in the diagnosis of ectopic pregnancy: A meta-analysis

Ben W.J. Mol*, G. Lijmer Jeroen, Willem M. Ankum, Fulco Van der Veen, Patrick M.M. Bossuyt

*Corresponding author for this work

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Serum progesterone measurement has been advocated as a diagnostic tool in the non-invasive diagnosis of ectopic pregnancy. To assess the accuracy of a single serum progesterone measurement in the diagnosis of ectopic pregnancy, a meta-analysis was performed incorporating 26 studies evaluating the performance of single serum progesterone measurement in the diagnosis of ectopic pregnancy. A distinction was made in the diagnosis of pregnancy failure of any type versus viable intrauterine pregnancy and the diagnosis of ectopic pregnancy versus non-ectopic pregnancy. The reported sensitivity and specificity differed between the studies. Since there was a clear negative correlation between sensitivity and specificity, summary receiver-operating characteristic (ROC) curves could be estimated. The ROC curve for the diagnosis of pregnancy failure versus viable intrauterine pregnancy showed a good discriminative capacity. Single serum progesterone measurement could not discriminate between ectopic pregnancy and non-ectopic pregnancy. It is concluded that serum progesterone measurement can identify patients at risk for ectopic pregnancy, who need further evaluation, but its discriminative capacity is insufficient to diagnose ectopic pregnancy with certainty.

Original languageEnglish
Pages (from-to)3220-3227
Number of pages8
JournalHuman Reproduction
Volume13
Issue number11
DOIs
Publication statusPublished - 1 Jan 1998

Keywords

  • Diagnosis
  • Ectopic pregnancy
  • Meta-analysis
  • Serum progesterone measurement

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