The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan tegella cf. spitzbergensis

Margey Tadesse*, Jioji N. Tabudravu, Marcel Jaspars, Morten B. Strøm, Espen Hansen, Jeanette H. Andersen, Per E. Kristiansen, Tor Haug

*Corresponding author for this work

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21 Citations (Scopus)

Abstract

The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.

Original languageEnglish
Pages (from-to)837-841
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number4
DOIs
Publication statusPublished - 25 Apr 2011

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ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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