The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting

Seyed Hashemi; Mojtaba Baktashian; Kiana Moghaddam; Mansoor Salehi; Sara Soflaei; Gordon Ferns; Alireza Pasdar; Majid Mobarhan

doi:10.4103/jrms.JRMS_293_18

The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting

Seyed Hashemi, Mojtaba Baktashian, Kiana Moghaddam, Mansoor Salehi, Sara Soflaei, Gordon Ferns, Alireza Pasdar^* (Corresponding Author), Majid Mobarhan^* (Corresponding Author)

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Advances in the technology for percutaneous coronary angioplasty, such as coated stents, have reduced its complications, but restenosis remains an important clinical problem. The factors associated with an increased risk of restenosis include diabetes mellitus and multiple coronary artery disease. It is also possible that genetic factors play a role in restenosis although there are little data on this. We have investigated the association of three genetic markers of genes involved in inflammation leading to restenosis.Materials and Methods: In this case-control study, 306 unrelated Iranian patients who were thought to have restenosis on clinical grounds were investigated. Based on the results of angiography, 104 patients were found to have >50% stenosis within an implanted stent, and these were allocated to the in-stent restenosis (ISR) group; 202 patients with no in-stent stenosis or stenosis ≤50% were allocated to the non-ISR (NISR) group. Demographic data were collected from medical records. Biochemical parameters were measured using routine methods. Genotypes of the interleukin-10 (IL-10), annexin A5 (AnxA5), and tumor necrosis factor-alpha (TNF) loci were determined using real-time polymerase chain reaction and a high-resolution melting assay. Results: Fasting blood glucose, serum triglycerides, and serum high-sensitivity C-reactive protein (hs-CRP) concentrations were higher in the ISR group than in the NISR group (P < 0.05), and a history of diabetes mellitus was significantly related to the presence of restenosis (P < 0.001). There were no significant differences in the frequency of the genetic polymorphisms of IL-10, AnxA5, and TNF genes and the presence of ISR. Conclusion: After adjustment for clinical variables, the genetic polymorphisms at the IL-10, TNF, and ANXA5 gene loci do not appear to be risk factors for >50% ISR in our population. However, our data suggested a significant association between diabetes mellitus, serum hs-CRP, stent type, and restenosis.

Original language	English
Article number	263379
Journal	Journal of Research in Medical Sciences
Volume	24
Issue number	1
Early online date	24 Jul 2019
DOIs	https://doi.org/10.4103/jrms.JRMS_293_18
Publication status	Published - 2019

Keywords

Annexin A5
in-stent restenosis
interleukin-10
single-nucleotide polymorphism
tumor-necrotizing factor

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Hashemi, S., Baktashian, M., Moghaddam, K., Salehi, M., Soflaei, S., Ferns, G., Pasdar, A., & Mobarhan, M. (2019). The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting. Journal of Research in Medical Sciences, 24(1), [263379]. https://doi.org/10.4103/jrms.JRMS_293_18

The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting. / Hashemi, Seyed; Baktashian, Mojtaba; Moghaddam, Kiana et al.

In: Journal of Research in Medical Sciences, Vol. 24, No. 1, 263379, 2019.

Research output: Contribution to journal › Article › peer-review

Hashemi, S, Baktashian, M, Moghaddam, K, Salehi, M, Soflaei, S, Ferns, G, Pasdar, A & Mobarhan, M 2019, 'The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting', Journal of Research in Medical Sciences, vol. 24, no. 1, 263379. https://doi.org/10.4103/jrms.JRMS_293_18

Hashemi S, Baktashian M, Moghaddam K, Salehi M, Soflaei S, Ferns G et al. The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting. Journal of Research in Medical Sciences. 2019;24(1):263379. Epub 2019 Jul 24. doi: 10.4103/jrms.JRMS_293_18

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title = "The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting",

abstract = "Background: Advances in the technology for percutaneous coronary angioplasty, such as coated stents, have reduced its complications, but restenosis remains an important clinical problem. The factors associated with an increased risk of restenosis include diabetes mellitus and multiple coronary artery disease. It is also possible that genetic factors play a role in restenosis although there are little data on this. We have investigated the association of three genetic markers of genes involved in inflammation leading to restenosis.Materials and Methods: In this case-control study, 306 unrelated Iranian patients who were thought to have restenosis on clinical grounds were investigated. Based on the results of angiography, 104 patients were found to have >50% stenosis within an implanted stent, and these were allocated to the in-stent restenosis (ISR) group; 202 patients with no in-stent stenosis or stenosis ≤50% were allocated to the non-ISR (NISR) group. Demographic data were collected from medical records. Biochemical parameters were measured using routine methods. Genotypes of the interleukin-10 (IL-10), annexin A5 (AnxA5), and tumor necrosis factor-alpha (TNF) loci were determined using real-time polymerase chain reaction and a high-resolution melting assay. Results: Fasting blood glucose, serum triglycerides, and serum high-sensitivity C-reactive protein (hs-CRP) concentrations were higher in the ISR group than in the NISR group (P < 0.05), and a history of diabetes mellitus was significantly related to the presence of restenosis (P < 0.001). There were no significant differences in the frequency of the genetic polymorphisms of IL-10, AnxA5, and TNF genes and the presence of ISR. Conclusion: After adjustment for clinical variables, the genetic polymorphisms at the IL-10, TNF, and ANXA5 gene loci do not appear to be risk factors for >50% ISR in our population. However, our data suggested a significant association between diabetes mellitus, serum hs-CRP, stent type, and restenosis.",

keywords = "Annexin A5, in-stent restenosis, interleukin-10, single-nucleotide polymorphism, tumor-necrotizing factor",

author = "Seyed Hashemi and Mojtaba Baktashian and Kiana Moghaddam and Mansoor Salehi and Sara Soflaei and Gordon Ferns and Alireza Pasdar and Majid Mobarhan",

note = "Acknowledgments We would like to thank Dr. Maracy, Ms. Sedghi, Ms. Gholamrezapour, Ms. Asadi and technicians of AL Zahra hospital's genetic laboratory and catheterization laboratory nurses of Sina Hospital, Iran. Financial support and sponsorship This study was supported by grants from Medical University of Isfahan (No: 1141292) and Medical University of Mashhad (No: 93570), Iran",

year = "2019",

doi = "10.4103/jrms.JRMS_293_18",

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T1 - The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting

AU - Hashemi, Seyed

AU - Baktashian, Mojtaba

AU - Moghaddam, Kiana

AU - Salehi, Mansoor

AU - Soflaei, Sara

AU - Ferns, Gordon

AU - Pasdar, Alireza

AU - Mobarhan, Majid

N1 - Acknowledgments We would like to thank Dr. Maracy, Ms. Sedghi, Ms. Gholamrezapour, Ms. Asadi and technicians of AL Zahra hospital's genetic laboratory and catheterization laboratory nurses of Sina Hospital, Iran. Financial support and sponsorship This study was supported by grants from Medical University of Isfahan (No: 1141292) and Medical University of Mashhad (No: 93570), Iran

PY - 2019

Y1 - 2019

N2 - Background: Advances in the technology for percutaneous coronary angioplasty, such as coated stents, have reduced its complications, but restenosis remains an important clinical problem. The factors associated with an increased risk of restenosis include diabetes mellitus and multiple coronary artery disease. It is also possible that genetic factors play a role in restenosis although there are little data on this. We have investigated the association of three genetic markers of genes involved in inflammation leading to restenosis.Materials and Methods: In this case-control study, 306 unrelated Iranian patients who were thought to have restenosis on clinical grounds were investigated. Based on the results of angiography, 104 patients were found to have >50% stenosis within an implanted stent, and these were allocated to the in-stent restenosis (ISR) group; 202 patients with no in-stent stenosis or stenosis ≤50% were allocated to the non-ISR (NISR) group. Demographic data were collected from medical records. Biochemical parameters were measured using routine methods. Genotypes of the interleukin-10 (IL-10), annexin A5 (AnxA5), and tumor necrosis factor-alpha (TNF) loci were determined using real-time polymerase chain reaction and a high-resolution melting assay. Results: Fasting blood glucose, serum triglycerides, and serum high-sensitivity C-reactive protein (hs-CRP) concentrations were higher in the ISR group than in the NISR group (P < 0.05), and a history of diabetes mellitus was significantly related to the presence of restenosis (P < 0.001). There were no significant differences in the frequency of the genetic polymorphisms of IL-10, AnxA5, and TNF genes and the presence of ISR. Conclusion: After adjustment for clinical variables, the genetic polymorphisms at the IL-10, TNF, and ANXA5 gene loci do not appear to be risk factors for >50% ISR in our population. However, our data suggested a significant association between diabetes mellitus, serum hs-CRP, stent type, and restenosis.

AB - Background: Advances in the technology for percutaneous coronary angioplasty, such as coated stents, have reduced its complications, but restenosis remains an important clinical problem. The factors associated with an increased risk of restenosis include diabetes mellitus and multiple coronary artery disease. It is also possible that genetic factors play a role in restenosis although there are little data on this. We have investigated the association of three genetic markers of genes involved in inflammation leading to restenosis.Materials and Methods: In this case-control study, 306 unrelated Iranian patients who were thought to have restenosis on clinical grounds were investigated. Based on the results of angiography, 104 patients were found to have >50% stenosis within an implanted stent, and these were allocated to the in-stent restenosis (ISR) group; 202 patients with no in-stent stenosis or stenosis ≤50% were allocated to the non-ISR (NISR) group. Demographic data were collected from medical records. Biochemical parameters were measured using routine methods. Genotypes of the interleukin-10 (IL-10), annexin A5 (AnxA5), and tumor necrosis factor-alpha (TNF) loci were determined using real-time polymerase chain reaction and a high-resolution melting assay. Results: Fasting blood glucose, serum triglycerides, and serum high-sensitivity C-reactive protein (hs-CRP) concentrations were higher in the ISR group than in the NISR group (P < 0.05), and a history of diabetes mellitus was significantly related to the presence of restenosis (P < 0.001). There were no significant differences in the frequency of the genetic polymorphisms of IL-10, AnxA5, and TNF genes and the presence of ISR. Conclusion: After adjustment for clinical variables, the genetic polymorphisms at the IL-10, TNF, and ANXA5 gene loci do not appear to be risk factors for >50% ISR in our population. However, our data suggested a significant association between diabetes mellitus, serum hs-CRP, stent type, and restenosis.

KW - Annexin A5

KW - in-stent restenosis

KW - interleukin-10

KW - single-nucleotide polymorphism

KW - tumor-necrotizing factor

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The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting

Abstract

Keywords

UN SDGs

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