The association between parity and spontaneous preterm birth: A population based study

Bouchra Koullali; Maud D. Van Zijl; Brenda M. Kazemier; Martijn A. Oudijk; Ben W.J. Mol; Eva Pajkrt; Anita C.J. Ravelli

doi:10.1186/s12884-020-02940-w

The association between parity and spontaneous preterm birth: A population based study

Bouchra Koullali^*, Maud D. Van Zijl, Brenda M. Kazemier, Martijn A. Oudijk, Ben W.J. Mol, Eva Pajkrt, Anita C.J. Ravelli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Preterm birth is the leading cause of perinatal mortality and neonatal morbidity worldwide. Many factors have been associated with preterm birth, including parity. The aim of the present study was to investigate associations between parity and risk of spontaneous preterm birth. Methods: We conducted a retrospective study including live singleton births (≥22 weeks) of women with a first, second, third, fourth or fifth pregnancy in The Netherlands from 2010 through 2014. Our primary outcome was risk of spontaneous preterm birth < 37 weeks. Secondary outcomes were spontaneous preterm birth < 32 and < 28 weeks. Results: We studied 802,119 pregnancies, including 30,237 pregnancies that ended spontaneously < 37 weeks. We identified an increased risk for spontaneous preterm birth < 37 weeks in nulliparous women (OR 1.95, 95% CI 1.89-2.00) and women in their fifth pregnancy (OR 1.26, 95% CI 1.13-1.41) compared to women in their second pregnancy. Similar results were seen for spontaneous preterm birth < 32 and < 28 weeks. Conclusion: Our data show an independent association between nulliparity and spontaneous preterm birth < 37, < 32 and < 28 weeks. Furthermore, we observed an increased risk for spontaneous preterm birth in women in their fifth pregnancy, with highest risk for preterm birth at early gestational age.

Original language	English
Article number	233
Number of pages	8
Journal	BMC Pregnancy and Childbirth
Volume	20
DOIs	https://doi.org/10.1186/s12884-020-02940-w
Publication status	Published - 21 Apr 2020

Bibliographical note

The authors thank the Dutch midwives, obstetricians, neonatologists, and other perinatal health care providers for the registration of perinatal information and the foundation of the Netherlands Perinatal Registry (www.perined.nl) for permission to use the registry data (approval no. 17.34).

Keywords

Nulliparity
Parity
Risk factors
Spontaneous preterm birth
MATERNAL AGE
GRAND MULTIPARITY
INCREASES
RISK
EPIDEMIOLOGY
PROBABILISTIC RECORD LINKAGE
PREGNANCY

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Cite this

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title = "The association between parity and spontaneous preterm birth: A population based study",

abstract = "Background: Preterm birth is the leading cause of perinatal mortality and neonatal morbidity worldwide. Many factors have been associated with preterm birth, including parity. The aim of the present study was to investigate associations between parity and risk of spontaneous preterm birth. Methods: We conducted a retrospective study including live singleton births (≥22 weeks) of women with a first, second, third, fourth or fifth pregnancy in The Netherlands from 2010 through 2014. Our primary outcome was risk of spontaneous preterm birth < 37 weeks. Secondary outcomes were spontaneous preterm birth < 32 and < 28 weeks. Results: We studied 802,119 pregnancies, including 30,237 pregnancies that ended spontaneously < 37 weeks. We identified an increased risk for spontaneous preterm birth < 37 weeks in nulliparous women (OR 1.95, 95% CI 1.89-2.00) and women in their fifth pregnancy (OR 1.26, 95% CI 1.13-1.41) compared to women in their second pregnancy. Similar results were seen for spontaneous preterm birth < 32 and < 28 weeks. Conclusion: Our data show an independent association between nulliparity and spontaneous preterm birth < 37, < 32 and < 28 weeks. Furthermore, we observed an increased risk for spontaneous preterm birth in women in their fifth pregnancy, with highest risk for preterm birth at early gestational age.",

keywords = "Nulliparity, Parity, Risk factors, Spontaneous preterm birth, MATERNAL AGE, GRAND MULTIPARITY, INCREASES, RISK, EPIDEMIOLOGY, PROBABILISTIC RECORD LINKAGE, PREGNANCY",

author = "Bouchra Koullali and {Van Zijl}, {Maud D.} and Kazemier, {Brenda M.} and Oudijk, {Martijn A.} and Mol, {Ben W.J.} and Eva Pajkrt and Ravelli, {Anita C.J.}",

note = "The authors thank the Dutch midwives, obstetricians, neonatologists, and other perinatal health care providers for the registration of perinatal information and the foundation of the Netherlands Perinatal Registry (www.perined.nl) for permission to use the registry data (approval no. 17.34). ",

year = "2020",

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doi = "10.1186/s12884-020-02940-w",

language = "English",

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T2 - A population based study

AU - Koullali, Bouchra

AU - Van Zijl, Maud D.

AU - Kazemier, Brenda M.

AU - Oudijk, Martijn A.

AU - Mol, Ben W.J.

AU - Pajkrt, Eva

AU - Ravelli, Anita C.J.

N1 - The authors thank the Dutch midwives, obstetricians, neonatologists, and other perinatal health care providers for the registration of perinatal information and the foundation of the Netherlands Perinatal Registry (www.perined.nl) for permission to use the registry data (approval no. 17.34).

PY - 2020/4/21

Y1 - 2020/4/21

N2 - Background: Preterm birth is the leading cause of perinatal mortality and neonatal morbidity worldwide. Many factors have been associated with preterm birth, including parity. The aim of the present study was to investigate associations between parity and risk of spontaneous preterm birth. Methods: We conducted a retrospective study including live singleton births (≥22 weeks) of women with a first, second, third, fourth or fifth pregnancy in The Netherlands from 2010 through 2014. Our primary outcome was risk of spontaneous preterm birth < 37 weeks. Secondary outcomes were spontaneous preterm birth < 32 and < 28 weeks. Results: We studied 802,119 pregnancies, including 30,237 pregnancies that ended spontaneously < 37 weeks. We identified an increased risk for spontaneous preterm birth < 37 weeks in nulliparous women (OR 1.95, 95% CI 1.89-2.00) and women in their fifth pregnancy (OR 1.26, 95% CI 1.13-1.41) compared to women in their second pregnancy. Similar results were seen for spontaneous preterm birth < 32 and < 28 weeks. Conclusion: Our data show an independent association between nulliparity and spontaneous preterm birth < 37, < 32 and < 28 weeks. Furthermore, we observed an increased risk for spontaneous preterm birth in women in their fifth pregnancy, with highest risk for preterm birth at early gestational age.

AB - Background: Preterm birth is the leading cause of perinatal mortality and neonatal morbidity worldwide. Many factors have been associated with preterm birth, including parity. The aim of the present study was to investigate associations between parity and risk of spontaneous preterm birth. Methods: We conducted a retrospective study including live singleton births (≥22 weeks) of women with a first, second, third, fourth or fifth pregnancy in The Netherlands from 2010 through 2014. Our primary outcome was risk of spontaneous preterm birth < 37 weeks. Secondary outcomes were spontaneous preterm birth < 32 and < 28 weeks. Results: We studied 802,119 pregnancies, including 30,237 pregnancies that ended spontaneously < 37 weeks. We identified an increased risk for spontaneous preterm birth < 37 weeks in nulliparous women (OR 1.95, 95% CI 1.89-2.00) and women in their fifth pregnancy (OR 1.26, 95% CI 1.13-1.41) compared to women in their second pregnancy. Similar results were seen for spontaneous preterm birth < 32 and < 28 weeks. Conclusion: Our data show an independent association between nulliparity and spontaneous preterm birth < 37, < 32 and < 28 weeks. Furthermore, we observed an increased risk for spontaneous preterm birth in women in their fifth pregnancy, with highest risk for preterm birth at early gestational age.

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KW - Parity

KW - Risk factors

KW - Spontaneous preterm birth

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KW - INCREASES

KW - RISK

KW - EPIDEMIOLOGY

KW - PROBABILISTIC RECORD LINKAGE

KW - PREGNANCY

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DO - 10.1186/s12884-020-02940-w

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SN - 1471-2393

VL - 20

JO - BMC Pregnancy and Childbirth

JF - BMC Pregnancy and Childbirth

M1 - 233

ER -

The association between parity and spontaneous preterm birth: A population based study

Abstract

Bibliographical note

Keywords

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