Abstract
During infection, the acute phase response triggers the release of acute phase proteins (APP), alpha-(1), acid glycoprotein (AGP), serum amyloid A (SAA) and Pig-MAP into the circulation, accompanied by a decrease in plasma levels of transthyretin. We quantified the association between these APP in 26 apparently healthy pigs from two breeds, 13 Large White and 13 Meishan (16 male; 10 female). There was a significant correlation between plasma levels of haptoglobin and Pig-MAP (r = 0.57;p < 0.05), but no significant associations between any of the other APP tested. We also measured the relationship between PigMAP, transthyretin and SAA, and the proportions of peripheral blood mononuclear sub-sets, CD8(+) cells, CD4(+) cells, CD11R1(+) cells, MHC DQ(+) cells, and monocytes. There were correlations between both plasma levels of Pig-MAP and the proportion of monocytes (r = 0.55; p < 0.05) and plasma levels of transthyretin and the proportion of MHC DQ(+) cells (r = 0.40; p < 0.01). Breed and sex influenced plasma levels of Pig-MAP but not plasma levels of transthyretin. Overall, these results suggest closer links between the mechanisms that regulate the release haptoglobin, Pig-MAP and monocytes compared to those that regulate the release of AGP, SAA and transthyretin.
Original language | English |
---|---|
Pages (from-to) | 303-309 |
Number of pages | 7 |
Journal | Veterinary Immunology and Immunopathology |
Volume | 119 |
Issue number | 3-4 |
Early online date | 2 Jun 2007 |
DOIs | |
Publication status | Published - 15 Oct 2007 |
Keywords
- acute phase proteins
- correlations
- pigs
- Large White
- Meishan
- quantitative trait loci
- C-reactive protein
- monoclonal-antibodies
- streptococcus-suis
- infection
- endotoxin
- selection
- growth
- swine
- Acute phase proteins
- large white
- meishan