The Authors Reply: Reply to 'Is the Heart Really Stressed Out of Energy?'

Dana K Dawson, Christopher J Neil, Anke Henning, Donnie Cameron, Baljit Jagpal, Margaret Bruce, John Horowitz, Michael P Frenneaux

Research output: Contribution to journalComment/debatepeer-review


Refers To
Zhongxia Sun, Pahul Singh, Tiemin Wei, Hani Kozman, Kan Liu
Is the Heart Really Stressed Out of Energy? JACC: Cardiovascular Imaging, Volume 9, Issue 5, May 2016, Pages 633-635

We thank Dr. Sun and colleagues for their interest in our publication (1) and for their questions that highlight important pathophysiological phenomena that appear unique to Tako-tsubo cardiomyopathy (TTC).

It is true that for the same extent of left ventricular (LV) systolic impairment and indeed for the same degree of elevation of LV end-diastolic pressure (2), patients appear to have lesser degrees of pulmonary edema in acute TTC compared with those experiencing a large acute myocardial infarction (AMI). However, this does not mean that the clinical course in the early stages of acute TTC is “benign.” Conversely, there are significant hemodynamic, arrhythmic, and embolic complications, all of which are life threatening and place the early in-hospital mortality of acute TTC on par with that of AMI
Original languageEnglish
Pages (from-to)635-636
Number of pages2
JournalJACC. Cardiovascular Imaging
Issue number5
Early online date17 Feb 2016
Publication statusPublished - May 2016


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