The bioavallability of raspberry anthocyanins and ellagitannins in rats

Gina Borges, Suri Roowi, Jean-Max Rouanet, Garry G. Duthie, Michael E. J. Lean, Alan Crozier

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The fate of anthocyanins and ellagitannins in rats was monitored following ingestion of raspberry juice. After 1 h low nM concentrations of unmetabolised anthocyanins were present in plasma but these declined by 2 h and after 4 h they were no longer detectable. For the first 2 h there was an almost full recovery of anthocyanins as they passed from the stomach through the duodenum/jejunum and into the ileum. After 3 h less than 50% were recovered, and the levels declined rapidly thereafter. Excretion of raspberry anthocyanins in urine over a 24 h period was equivalent to 1.2% of the amount ingested. Trace quantities of anthocyanins were detected in the caecum, colon and faeces and they were absent in extracts of liver, kidneys and brain. Urine also contained a number of phenolic acids but most were present in quantities well in excess of the 918 nmol of anthocyanins present in the ingested juice. These findings indicate that raspberry anthocyanins per se are poorly absorbed, probably prior to reaching the ileum, and that substantial amounts pass from the small to the large intestine where they are degraded by colonic bacteria. Ellagitannins disappeared in the stomach without accumulation of ellagic acid.

Original languageEnglish
Pages (from-to)714-725
Number of pages12
JournalMolecular Nutrition & Food Research
Volume51
Issue number6
Early online date29 May 2007
DOIs
Publication statusPublished - Jun 2007

Keywords

  • anthocyanins
  • bioavailability
  • ellagitannins
  • raspberries
  • rats
  • tandem mass-spectrometry
  • cyanidin3-O-beta-D-glucopyranoside
  • flavonol metabolites
  • antioxidant activity
  • in-vitro
  • absorption
  • juice
  • microflora
  • capacity
  • stomach

Cite this

The bioavallability of raspberry anthocyanins and ellagitannins in rats. / Borges, Gina; Roowi, Suri; Rouanet, Jean-Max; Duthie, Garry G.; Lean, Michael E. J.; Crozier, Alan.

In: Molecular Nutrition & Food Research, Vol. 51, No. 6, 06.2007, p. 714-725.

Research output: Contribution to journalArticle

Borges, Gina ; Roowi, Suri ; Rouanet, Jean-Max ; Duthie, Garry G. ; Lean, Michael E. J. ; Crozier, Alan. / The bioavallability of raspberry anthocyanins and ellagitannins in rats. In: Molecular Nutrition & Food Research. 2007 ; Vol. 51, No. 6. pp. 714-725.
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