The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance

J E R Britton, S M Wilkinson, J S C English, D J Gawkrodger, Anthony Ormerod, J E Sansom, S Shaw, B Statham

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: All centres use an empirically determined set of 'standard' test allergens for patch testing that contain the commoner environmental sensitizers. Objectives To assess the validity of the British standard series of 12 allergens used in addition to the 23 already in the European standard series. PATIENTS AND METHODS: Results for 3062 consecutive patients patch tested in seven centres across the United Kingdom during the year 2000 were analysed. RESULTS: The additional allergens from the British series and positive rates were: methyl dibromoglutaronitrile 2.4%, carba mix 1.6%, tixocortol pivalate 1.5%, ethylenediamine 1.3%, cetearyl alcohol 0.8%, 2-bromo-2-nitropane-1,3-diol 0.8%, diazolidinyl urea 0.7%, chlorocresol 0.6%, budesonide 0.6%, fusidic acid 0.5%, imidazolidinyl urea 0.5%, and chloroxylenol 0.4%. The allergens with the lowest positive rate in the European standard series were primin at 0.6% and isopropyl-phenyl-para-phenylenediamine at 0.4%. CONCLUSIONS: The 12 allergens in the British series should continue being tested as a standard addition to the European series within the U.K. The collection of data in this manner to allow comparisons between centres shows differences that reflect selection criteria and interpretation of results, and offers a useful tool for audit and clinical governance. Testing fewer than 1 : 2150 population may indicate underprovision of service. Similarly, rates of sensitization for nickel contact allergy above 26% and for fragrance mix above 16% (the upper 95% confidence intervals) should stimulate inquiry into the reasons behind this.
Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalBritish Journal of Dermatology
Volume148
Issue number2
DOIs
Publication statusPublished - 1 Feb 2003

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Clinical Governance
Contact Dermatitis
Allergens
ethylenediamine
Fusidic Acid
Budesonide
Patch Tests
Nickel
Patient Selection
Hypersensitivity
Confidence Intervals
Population

Keywords

  • Allergens
  • Dermatitis, Contact
  • Ditiocarb
  • Great Britain
  • Guanidines
  • Humans
  • Patch Tests
  • Reference Standards
  • Retrospective Studies
  • Thiocarbamates
  • British standard series
  • Contact Dermatitis
  • European standard series
  • patch testing

Cite this

Britton, J. E. R., Wilkinson, S. M., English, J. S. C., Gawkrodger, D. J., Ormerod, A., Sansom, J. E., ... Statham, B. (2003). The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance. British Journal of Dermatology, 148(2), 259-264. https://doi.org/10.1046/j.1365-2133.2003.05170.x

The British standard series of contact dermatitis allergens : validation in clinical practice and value for clinical governance. / Britton, J E R; Wilkinson, S M; English, J S C; Gawkrodger, D J; Ormerod, Anthony; Sansom, J E; Shaw, S; Statham, B.

In: British Journal of Dermatology, Vol. 148, No. 2, 01.02.2003, p. 259-264.

Research output: Contribution to journalArticle

Britton, JER, Wilkinson, SM, English, JSC, Gawkrodger, DJ, Ormerod, A, Sansom, JE, Shaw, S & Statham, B 2003, 'The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance', British Journal of Dermatology, vol. 148, no. 2, pp. 259-264. https://doi.org/10.1046/j.1365-2133.2003.05170.x
Britton, J E R ; Wilkinson, S M ; English, J S C ; Gawkrodger, D J ; Ormerod, Anthony ; Sansom, J E ; Shaw, S ; Statham, B. / The British standard series of contact dermatitis allergens : validation in clinical practice and value for clinical governance. In: British Journal of Dermatology. 2003 ; Vol. 148, No. 2. pp. 259-264.
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abstract = "BACKGROUND: All centres use an empirically determined set of 'standard' test allergens for patch testing that contain the commoner environmental sensitizers. Objectives To assess the validity of the British standard series of 12 allergens used in addition to the 23 already in the European standard series. PATIENTS AND METHODS: Results for 3062 consecutive patients patch tested in seven centres across the United Kingdom during the year 2000 were analysed. RESULTS: The additional allergens from the British series and positive rates were: methyl dibromoglutaronitrile 2.4{\%}, carba mix 1.6{\%}, tixocortol pivalate 1.5{\%}, ethylenediamine 1.3{\%}, cetearyl alcohol 0.8{\%}, 2-bromo-2-nitropane-1,3-diol 0.8{\%}, diazolidinyl urea 0.7{\%}, chlorocresol 0.6{\%}, budesonide 0.6{\%}, fusidic acid 0.5{\%}, imidazolidinyl urea 0.5{\%}, and chloroxylenol 0.4{\%}. The allergens with the lowest positive rate in the European standard series were primin at 0.6{\%} and isopropyl-phenyl-para-phenylenediamine at 0.4{\%}. CONCLUSIONS: The 12 allergens in the British series should continue being tested as a standard addition to the European series within the U.K. The collection of data in this manner to allow comparisons between centres shows differences that reflect selection criteria and interpretation of results, and offers a useful tool for audit and clinical governance. Testing fewer than 1 : 2150 population may indicate underprovision of service. Similarly, rates of sensitization for nickel contact allergy above 26{\%} and for fragrance mix above 16{\%} (the upper 95{\%} confidence intervals) should stimulate inquiry into the reasons behind this.",
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N2 - BACKGROUND: All centres use an empirically determined set of 'standard' test allergens for patch testing that contain the commoner environmental sensitizers. Objectives To assess the validity of the British standard series of 12 allergens used in addition to the 23 already in the European standard series. PATIENTS AND METHODS: Results for 3062 consecutive patients patch tested in seven centres across the United Kingdom during the year 2000 were analysed. RESULTS: The additional allergens from the British series and positive rates were: methyl dibromoglutaronitrile 2.4%, carba mix 1.6%, tixocortol pivalate 1.5%, ethylenediamine 1.3%, cetearyl alcohol 0.8%, 2-bromo-2-nitropane-1,3-diol 0.8%, diazolidinyl urea 0.7%, chlorocresol 0.6%, budesonide 0.6%, fusidic acid 0.5%, imidazolidinyl urea 0.5%, and chloroxylenol 0.4%. The allergens with the lowest positive rate in the European standard series were primin at 0.6% and isopropyl-phenyl-para-phenylenediamine at 0.4%. CONCLUSIONS: The 12 allergens in the British series should continue being tested as a standard addition to the European series within the U.K. The collection of data in this manner to allow comparisons between centres shows differences that reflect selection criteria and interpretation of results, and offers a useful tool for audit and clinical governance. Testing fewer than 1 : 2150 population may indicate underprovision of service. Similarly, rates of sensitization for nickel contact allergy above 26% and for fragrance mix above 16% (the upper 95% confidence intervals) should stimulate inquiry into the reasons behind this.

AB - BACKGROUND: All centres use an empirically determined set of 'standard' test allergens for patch testing that contain the commoner environmental sensitizers. Objectives To assess the validity of the British standard series of 12 allergens used in addition to the 23 already in the European standard series. PATIENTS AND METHODS: Results for 3062 consecutive patients patch tested in seven centres across the United Kingdom during the year 2000 were analysed. RESULTS: The additional allergens from the British series and positive rates were: methyl dibromoglutaronitrile 2.4%, carba mix 1.6%, tixocortol pivalate 1.5%, ethylenediamine 1.3%, cetearyl alcohol 0.8%, 2-bromo-2-nitropane-1,3-diol 0.8%, diazolidinyl urea 0.7%, chlorocresol 0.6%, budesonide 0.6%, fusidic acid 0.5%, imidazolidinyl urea 0.5%, and chloroxylenol 0.4%. The allergens with the lowest positive rate in the European standard series were primin at 0.6% and isopropyl-phenyl-para-phenylenediamine at 0.4%. CONCLUSIONS: The 12 allergens in the British series should continue being tested as a standard addition to the European series within the U.K. The collection of data in this manner to allow comparisons between centres shows differences that reflect selection criteria and interpretation of results, and offers a useful tool for audit and clinical governance. Testing fewer than 1 : 2150 population may indicate underprovision of service. Similarly, rates of sensitization for nickel contact allergy above 26% and for fragrance mix above 16% (the upper 95% confidence intervals) should stimulate inquiry into the reasons behind this.

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