The Butyrivibrio fibrisolvens tet(W) gene is carried on the novel conjugative transposon TnB1230, which contains duplicated nitroreductase coding sequences

C M Melville, R Brunel, Harry James Flint, Karen Patricia Scott

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The Butyrivibrio fibrisolvens tet(W) gene is located on the conjugative transposon TnB1230. TnB1230 encodes transfer proteins with 48 to 67% identity to some of those encoded by Tn1549. tet(W) is flanked by directly repeated sequences with significant homology to oxygen-insensitive nitroreductases. The 340 nucleotides upstream of tet(W) are strongly conserved and are required for tetracycline resistance.

Original languageEnglish
Pages (from-to)3656-3659
Number of pages4
JournalJournal of Bacteriology
Issue number11
Publication statusPublished - Jun 2004


  • tetracycline resistance genes
  • DNA-sequences
  • human gut
  • bacteria
  • transcription
  • determinants
  • expression
  • mechanisms
  • element
  • rumen

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