The c-src Homologue Src64B Is Sufficient to Activate the Drosophila Cellular Immune Response

M J Williams

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src64B disrupts the sessile-haemocyte banding pattern. Though Src64B overexpression induced the formation of specialized haemocytes known as lamellocytes, its hyperactivation had no effect on circulating plasmatocyte concentration. Also, there is evidence of non-autonomous regulation as Src64B activity was observed in non-overexpressing plasmatocytes. Finally, Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.
Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalJournal of Innate Immunity
Volume1
Issue number4
Early online date8 Jan 2009
DOIs
Publication statusPublished - Jun 2009

Keywords

  • innate immunity
  • tyrosine kinase
  • haemocyte
  • Src

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