The characterisation and determinants of quality of life in ANCA associated vasculitis

Neil Basu, Andrew McClean, Lorraine Harper, Esther Nicole Amft, Neeraj Dhaun, Raashid A Luqmani, Mark A Little, David Rw Jayne, Oliver Flossmann, John McLaren, Vinod Kumar, Lars P Erwig, David M Reid, Gareth T Jones, Gary J Macfarlane

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Abstract

OBJECTIVES: To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV). METHODS: A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR). RESULTS: Cases (n=410) experienced similar QOL to chronic disease controls (n=318) (physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) (physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%). CONCLUSIONS: AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.
Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume73
Issue number1
Early online date25 Jan 2013
DOIs
Publication statusPublished - 2013

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Vasculitis
Disease control
Antineutrophil Cytoplasmic Antibodies
Cytoplasm
Quality of Life
Logistics
Antibodies
Health
Fatigue of materials
Population
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Chronic Disease
Logistic Models
Population Control
Fatigue
Case-Control Studies

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The characterisation and determinants of quality of life in ANCA associated vasculitis. / Basu, Neil; McClean, Andrew; Harper, Lorraine; Amft, Esther Nicole; Dhaun, Neeraj; Luqmani, Raashid A; Little, Mark A; Jayne, David Rw; Flossmann, Oliver; McLaren, John; Kumar, Vinod; Erwig, Lars P; Reid, David M; Jones, Gareth T; Macfarlane, Gary J.

In: Annals of the Rheumatic Diseases, Vol. 73, No. 1, 2013, p. 207-211.

Research output: Contribution to journalArticle

Basu, N, McClean, A, Harper, L, Amft, EN, Dhaun, N, Luqmani, RA, Little, MA, Jayne, DR, Flossmann, O, McLaren, J, Kumar, V, Erwig, LP, Reid, DM, Jones, GT & Macfarlane, GJ 2013, 'The characterisation and determinants of quality of life in ANCA associated vasculitis' Annals of the Rheumatic Diseases, vol. 73, no. 1, pp. 207-211. https://doi.org/10.1136/annrheumdis-2012-202750
Basu, Neil ; McClean, Andrew ; Harper, Lorraine ; Amft, Esther Nicole ; Dhaun, Neeraj ; Luqmani, Raashid A ; Little, Mark A ; Jayne, David Rw ; Flossmann, Oliver ; McLaren, John ; Kumar, Vinod ; Erwig, Lars P ; Reid, David M ; Jones, Gareth T ; Macfarlane, Gary J. / The characterisation and determinants of quality of life in ANCA associated vasculitis. In: Annals of the Rheumatic Diseases. 2013 ; Vol. 73, No. 1. pp. 207-211.
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T1 - The characterisation and determinants of quality of life in ANCA associated vasculitis

AU - Basu, Neil

AU - McClean, Andrew

AU - Harper, Lorraine

AU - Amft, Esther Nicole

AU - Dhaun, Neeraj

AU - Luqmani, Raashid A

AU - Little, Mark A

AU - Jayne, David Rw

AU - Flossmann, Oliver

AU - McLaren, John

AU - Kumar, Vinod

AU - Erwig, Lars P

AU - Reid, David M

AU - Jones, Gareth T

AU - Macfarlane, Gary J

PY - 2013

Y1 - 2013

N2 - OBJECTIVES: To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV). METHODS: A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR). RESULTS: Cases (n=410) experienced similar QOL to chronic disease controls (n=318) (physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) (physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%). CONCLUSIONS: AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.

AB - OBJECTIVES: To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV). METHODS: A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR). RESULTS: Cases (n=410) experienced similar QOL to chronic disease controls (n=318) (physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) (physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%). CONCLUSIONS: AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.

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DO - 10.1136/annrheumdis-2012-202750

M3 - Article

VL - 73

SP - 207

EP - 211

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 1

ER -