The conundrum of naming resistance gene determinants

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Abstract

I read with great interest the Leading article by Hall and Schwarz and the comments by Evans and Jacoby et al. regarding the ongoing debate on how resistance genes should be named such that the nomenclature is universally acceptable. Although I agree that numbering based upon sequence similarity is a sensible suggestion by Hall and Schwarz, I couldn’t agree more with the point of Evans, who suggests that a ≥2% cut-off value would not be appropriate in naming a particular gene. Firstly, I would like to point out that we need to work on a foundation that has been built rather than destroying it and starting all over again.
Original languageEnglish
Pages (from-to)3623-3624
Number of pages2
JournalJournal of Antimicrobial Chemotherapy
Volume71
Issue number12
Early online date17 Jul 2016
DOIs
Publication statusPublished - Dec 2016

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The conundrum of naming resistance gene determinants. / Lopes, Bruno Silvester.

In: Journal of Antimicrobial Chemotherapy, Vol. 71, No. 12, 12.2016, p. 3623-3624.

Research output: Contribution to journalLetter

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author = "Lopes, {Bruno Silvester}",
note = "Acknowledgements This letter is dedicated to the hard work of Karen Bush and George Jacoby and their team, who have worked relentlessly in assigning numbers to β-lactamase variants since 1997.",
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AB - I read with great interest the Leading article by Hall and Schwarz and the comments by Evans and Jacoby et al. regarding the ongoing debate on how resistance genes should be named such that the nomenclature is universally acceptable. Although I agree that numbering based upon sequence similarity is a sensible suggestion by Hall and Schwarz, I couldn’t agree more with the point of Evans, who suggests that a ≥2% cut-off value would not be appropriate in naming a particular gene. Firstly, I would like to point out that we need to work on a foundation that has been built rather than destroying it and starting all over again.

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