The cryptic path from epitope to clot: a story of two domains?

Our understanding of the pathogenesis of antiphospholipid syndrome is incomplete but in this issue, 2 papers, by Kuwana and colleagues and de Laat and colleagues, give significant new insights into the mechanisms underlying the generation of antiphospholipid antibodies as well as their heterogeneity and the significance of this in relation to thrombotic disease.