Counting backwards: The cyanobactin class of heterocyclases, exemplified by TruD, possess an almost unique combination of processivity, specificity, chemical versatility, and promiscuity. TruD is shown by biochemical assay to be an adenylase, and processes cysteines in a defined order. The entire substrate leader can be removed and TruD will process a single specific cysteine residue; however the role of leader is to permit processivity through a balance of recognition. ATP/AMP=adenosine tri/monophosphate; PPi=pyrophosphate.
|Number of pages||6|
|Journal||Angewandte Chemie International Edition|
|Early online date||8 Nov 2013|
|Publication status||Published - 23 Dec 2013|
- ribosomal peptide pathways