The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

Shih-Chin Cheng, Frank L. van de Veerdonk, Megan Lenardon, Monique Stoffels, Theo Plantinga, Sanne Smeekens, Lisa Rizzetto, Liliane Mukaremera, Kanya Preechasuth, Duccio Cavalieri, Thirumala Devi Kanneganti, Jos W. M. van der Meer, Bart Jan Kullberg, Leo A. B. Joosten, Neil A. R. Gow, Mihai G. Netea

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130 Citations (Scopus)

Abstract

In the mucosa, the immune pathways discriminating between colonizing and invasive Candida, thus inducing tolerance or inflammation, are poorly understood. Th17 responses induced by Candida albicans hyphae are central for the activation of mucosal antifungal immunity. An essential step for the discrimination between yeasts and hyphae and induction of Th17 responses is the activation of the inflammasome by C. albicans hyphae and the subsequent release of active IL-1 beta in macrophages. Inflammasome activation in macrophages results from differences in cell-wall architecture between yeasts and hyphae and is partly mediated by the dectin-1/Syk pathway. These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans. J. Leukoc. Biol. 90: 357-366; 2011.

Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalJournal of Leukocyte Biology
Volume90
Issue number2
Early online date29 Apr 2011
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Candida
  • colonization
  • invasion
  • IL-1 beta
  • IL-17
  • NLRP3 inflammasome
  • host-defense
  • fungal-infections
  • Chrons-Disease
  • immune-system
  • cell-wall
  • Dectin-1
  • recognition
  • macrophages
  • activation

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    Cheng, S-C., van de Veerdonk, F. L., Lenardon, M., Stoffels, M., Plantinga, T., Smeekens, S., Rizzetto, L., Mukaremera, L., Preechasuth, K., Cavalieri, D., Kanneganti, T. D., van der Meer, J. W. M., Kullberg, B. J., Joosten, L. A. B., Gow, N. A. R., & Netea, M. G. (2011). The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. Journal of Leukocyte Biology, 90(2), 357-366. https://doi.org/10.1189/jlb.1210702