The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

Shih-Chin Cheng; Frank L. van de Veerdonk; Megan Lenardon; Monique Stoffels; Theo Plantinga; Sanne Smeekens; Lisa Rizzetto; Liliane Mukaremera; Kanya Preechasuth; Duccio Cavalieri; Thirumala Devi Kanneganti; Jos W. M. van der Meer; Bart Jan Kullberg; Leo A. B. Joosten; Neil A. R. Gow; Mihai G. Netea

doi:10.1189/jlb.1210702

The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

Shih-Chin Cheng, Frank L. van de Veerdonk, Megan Lenardon, Monique Stoffels, Theo Plantinga, Sanne Smeekens, Lisa Rizzetto, Liliane Mukaremera, Kanya Preechasuth, Duccio Cavalieri, Thirumala Devi Kanneganti, Jos W. M. van der Meer, Bart Jan Kullberg, Leo A. B. Joosten, Neil A. R. Gow, Mihai G. Netea

Medical Sciences

Research output: Contribution to journal › Article › peer-review

161 Citations (Scopus)

Abstract

In the mucosa, the immune pathways discriminating between colonizing and invasive Candida, thus inducing tolerance or inflammation, are poorly understood. Th17 responses induced by Candida albicans hyphae are central for the activation of mucosal antifungal immunity. An essential step for the discrimination between yeasts and hyphae and induction of Th17 responses is the activation of the inflammasome by C. albicans hyphae and the subsequent release of active IL-1 beta in macrophages. Inflammasome activation in macrophages results from differences in cell-wall architecture between yeasts and hyphae and is partly mediated by the dectin-1/Syk pathway. These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans. J. Leukoc. Biol. 90: 357-366; 2011.

Original language	English
Pages (from-to)	357-366
Number of pages	10
Journal	Journal of Leukocyte Biology
Volume	90
Issue number	2
Early online date	29 Apr 2011
DOIs	https://doi.org/10.1189/jlb.1210702
Publication status	Published - Aug 2011

Keywords

Candida
colonization
invasion
IL-1 beta
IL-17
NLRP3 inflammasome
host-defense
fungal-infections
Chrons-Disease
immune-system
cell-wall
Dectin-1
recognition
macrophages
activation

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10.1189/jlb.1210702

http://www.jleukbio.org/content/90/2/357.long

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Cheng, S.-C., van de Veerdonk, F. L., Lenardon, M., Stoffels, M., Plantinga, T., Smeekens, S., Rizzetto, L., Mukaremera, L., Preechasuth, K., Cavalieri, D., Kanneganti, T. D., van der Meer, J. W. M., Kullberg, B. J., Joosten, L. A. B., Gow, N. A. R., & Netea, M. G. (2011). The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. Journal of Leukocyte Biology, 90(2), 357-366. https://doi.org/10.1189/jlb.1210702

The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. / Cheng, Shih-Chin; van de Veerdonk, Frank L.; Lenardon, Megan et al.
In: Journal of Leukocyte Biology, Vol. 90, No. 2, 08.2011, p. 357-366.

Research output: Contribution to journal › Article › peer-review

Cheng, S-C, van de Veerdonk, FL, Lenardon, M, Stoffels, M, Plantinga, T, Smeekens, S, Rizzetto, L, Mukaremera, L, Preechasuth, K, Cavalieri, D, Kanneganti, TD, van der Meer, JWM, Kullberg, BJ, Joosten, LAB, Gow, NAR & Netea, MG 2011, 'The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans', Journal of Leukocyte Biology, vol. 90, no. 2, pp. 357-366. https://doi.org/10.1189/jlb.1210702

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abstract = "In the mucosa, the immune pathways discriminating between colonizing and invasive Candida, thus inducing tolerance or inflammation, are poorly understood. Th17 responses induced by Candida albicans hyphae are central for the activation of mucosal antifungal immunity. An essential step for the discrimination between yeasts and hyphae and induction of Th17 responses is the activation of the inflammasome by C. albicans hyphae and the subsequent release of active IL-1 beta in macrophages. Inflammasome activation in macrophages results from differences in cell-wall architecture between yeasts and hyphae and is partly mediated by the dectin-1/Syk pathway. These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans. J. Leukoc. Biol. 90: 357-366; 2011.",

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The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

Abstract

Keywords

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