The Dectin-2 family of C-type lectin-like receptors: an update

Bernhard Kerscher, Janet A. Willment, Gordon D. Brown

Research output: Contribution to journalArticle

102 Citations (Scopus)
5 Downloads (Pure)

Abstract

Myeloid and non-myeloid cells express members of the C-type lectin-like receptor (CTLR) family, which mediate crucial cellular functions during immunity and homeostasis. Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell immunoactivating receptor (DCAR), dendritic cell immunoreceptor (DCIR), Dectin-2, C-type lectin superfamily 8 (CLECSF8) and macrophage-inducible C-type lectin (Mincle). These CTLRs possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules. These receptors recognize a diverse range of endogenous and exogenous ligands, and can function as pattern recognition receptors for several classes of pathogens including fungi, bacteria and parasites, driving both innate and adaptive immunity. In this review, we summarize our knowledge of each of these receptors, highlighting the exciting discoveries that have been made in recent years.
Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalInternational Immunology
Volume25
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • C-type lectin-like receptor
  • carbohydrate recognition domain
  • ITAM
  • ITIM
  • pattern recognition receptor

Fingerprint Dive into the research topics of 'The Dectin-2 family of C-type lectin-like receptors: an update'. Together they form a unique fingerprint.

Cite this