The Dectin-2 family of C-type lectins in immunity and homeostasis

Lisa M. Graham, Gordon D. Brown

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

C-type lectins are a diverse family of proteins which recognize a wide range of ligands. This review focuses on the Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes are clustered in the telomeric region of the NK-gene cluster on mouse chromosome 6 and human chromosome 12. These type II receptors are expressed on myeloid and non-myeloid cells and contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation, whereas Mincle recognizes a nuclear protein released by necrotic cells. Here we review each of these receptors in detail describing their expression, ligand recognition, signalling and known physiological functions.
Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalCytokine
Volume48
Issue number1-2
DOIs
Publication statusPublished - Oct 2009

    Fingerprint

Keywords

  • animals
  • homeostasis
  • humans
  • lectins, C-type
  • membrane glycoproteins
  • membrane proteins
  • mice
  • receptors, immunologic
  • C-type lectin
  • carbohydrate recognition domain
  • ITAM
  • ITIM

Cite this