Abstract
Objectives: The purpose of the present study was to determine whether a community-based walking intervention, using pedometers, is effective in reducing systemic inflammatory markers.
Methods: Participants (age = 49(8.9)) were recruited in Glasgow, United Kingdom, from August to December 2006 and were randomly assigned to a control (n = 24; 6 males, no change in walking) and intervention group (n = 24; 5 males gradually increasing walking by 3000 steps/day on 5 days of the week). Blood samples were collected at baseline, and after 12 weeks, and analysed for glucose, insulin, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumour necrosis factor-alpha (TNF-a) and soluble TNF receptors I and II (sTNFR1 and sTNFRII).
Results: In the control group baseline step counts were 6356 (2953) steps/day and did not change (P > 0.05) after 12 weeks, 6709 (2918) steps/day. The intervention group increased (P < 0.001) step count from 6682 (3761) steps/day at baseline to 10182 (4081) steps/day at 12 weeks. Over the 12 week period there was no change in any other variables measured, in either control or intervention group.
Conclusion: We conclude that the current community-based intervention did not affect systemic markers of inflammation or insulin sensitivity.
Methods: Participants (age = 49(8.9)) were recruited in Glasgow, United Kingdom, from August to December 2006 and were randomly assigned to a control (n = 24; 6 males, no change in walking) and intervention group (n = 24; 5 males gradually increasing walking by 3000 steps/day on 5 days of the week). Blood samples were collected at baseline, and after 12 weeks, and analysed for glucose, insulin, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumour necrosis factor-alpha (TNF-a) and soluble TNF receptors I and II (sTNFR1 and sTNFRII).
Results: In the control group baseline step counts were 6356 (2953) steps/day and did not change (P > 0.05) after 12 weeks, 6709 (2918) steps/day. The intervention group increased (P < 0.001) step count from 6682 (3761) steps/day at baseline to 10182 (4081) steps/day at 12 weeks. Over the 12 week period there was no change in any other variables measured, in either control or intervention group.
Conclusion: We conclude that the current community-based intervention did not affect systemic markers of inflammation or insulin sensitivity.
| Original language | English |
|---|---|
| Pages (from-to) | 39-44 |
| Number of pages | 6 |
| Journal | Preventive Medicine |
| Volume | 48 |
| Issue number | 1 |
| Early online date | 29 Oct 2008 |
| DOIs | |
| Publication status | Published - Jan 2009 |
Keywords
- adolescent
- adult
- aged
- biological markers
- female
- humans
- insulin resistance
- male
- middle aged
- monitoring, physiologic
- Scotland
- systemic inflammatory response syndrome
- walking
- young adult
- physical activity
- pedometers
- inflammation