The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation

Stuart R Gray, Graham Baker, Annemarie Wright, Claire F Fitzsimons, Nanette Mutrie, Myra A Nimmo, Scottish Physical Activity Research Collaboration (SPARColl)

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Objectives: The purpose of the present study was to determine whether a community-based walking intervention, using pedometers, is effective in reducing systemic inflammatory markers.

Methods: Participants (age = 49(8.9)) were recruited in Glasgow, United Kingdom, from August to December 2006 and were randomly assigned to a control (n = 24; 6 males, no change in walking) and intervention group (n = 24; 5 males gradually increasing walking by 3000 steps/day on 5 days of the week). Blood samples were collected at baseline, and after 12 weeks, and analysed for glucose, insulin, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumour necrosis factor-alpha (TNF-a) and soluble TNF receptors I and II (sTNFR1 and sTNFRII).

Results: In the control group baseline step counts were 6356 (2953) steps/day and did not change (P > 0.05) after 12 weeks, 6709 (2918) steps/day. The intervention group increased (P < 0.001) step count from 6682 (3761) steps/day at baseline to 10182 (4081) steps/day at 12 weeks. Over the 12 week period there was no change in any other variables measured, in either control or intervention group.

Conclusion: We conclude that the current community-based intervention did not affect systemic markers of inflammation or insulin sensitivity.
Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalPreventive Medicine
Issue number1
Early online date29 Oct 2008
Publication statusPublished - Jan 2009


  • adolescent
  • adult
  • aged
  • biological markers
  • female
  • humans
  • insulin resistance
  • male
  • middle aged
  • monitoring, physiologic
  • Scotland
  • systemic inflammatory response syndrome
  • walking
  • young adult
  • physical activity
  • pedometers
  • inflammation


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