The effect of COVID-19 mRNA vaccines against postvaccination laboratory-confirmed SARS-CoV-2 infection, symptomatic COVID-19 infection, hospitalization, and mortality rate: a systematic review and meta-analysis

Hamid Reza Baradaran, Hojat Dehghanbanadaki, Farhad Moradpour, Babak Eshrati, Ghobad Moradi, Mobin Azami, Abdolkarim Haji Ghadery, Mohammad Mehdi Mehrabi Nejad, Yousef Moradi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objectives: We systematically reviewed the literature to investigate the pooled effect of COVID-19 mRNA vaccination against SARS-CoV-2 infection and its clinical outcomes. Methods: Scopus, Web of Science, PubMed (Medline), and Embase were searched on 9 September 2021. The odds ratio (OR) of COVID-19 infection and its clinical outcomes in fully/ partially vaccinated versus unvaccinated participants were calculated and pooled by using a random-effects model. Results: The pooled analysis showed that among health care workers and general population, vaccinated participants with one or two doses were less likely to infect with SARS-CoV-2 (OR = 0.16; 95%CI: 0.08–0.32; I2 = 79.86%; 95%CI I2: 68.99–87.21%), to develop symptomatic COVID-19 infection (OR = 0.09; 95%CI: 0.03–0.32; I2 = 80.43%; 95%CI I2: 70.83–89.33%), to admit to the hospital because of COVID-19 (OR = 0.13; 95%CI: 0.06–0.28; I2 = 86.19%; 95%CI I2: 67.80–93.88%), and to die from COVID-19 (OR = 0.14; 95%CI: 0.06–0.35; I2 = 66.76%; 95%CI I2: 54.00–76.99%) than unvaccinated participants. Conclusions: COVID-19 mRNA vaccines, especially following administration of two doses, are extremely effective. It would be suggested further studies with large sample size and different ethnicities to be conducted among the general population to warrant these results.

Original languageEnglish
Pages (from-to)1455-1464
Number of pages10
JournalExpert review of vaccines
Volume21
Issue number10
Early online date22 Jul 2022
DOIs
Publication statusPublished - 1 Jan 2023

Bibliographical note

Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • COVID-19
  • effectiveness
  • meta-analysis
  • mRNA
  • SARS-CoV-2
  • vaccine

Fingerprint

Dive into the research topics of 'The effect of COVID-19 mRNA vaccines against postvaccination laboratory-confirmed SARS-CoV-2 infection, symptomatic COVID-19 infection, hospitalization, and mortality rate: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this