The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Lotfolah Saed, Fatemeh Varse, Hamid Reza Baradaran, Yousef Moradi (Corresponding Author), Sorour Khateri, Emilie Friberg, Zaher Khazaei, Saeedeh Gharahjeh, Shahrzad Tehrani, Amir-Babak Sioofy-Khojine, Zahra Najmi

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.

METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.

RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97).

CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

Original languageEnglish
Article number527
Number of pages10
JournalBMC Cancer
Volume19
DOIs
Publication statusPublished - 31 May 2019

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Endometrial Neoplasms
Meta-Analysis
Case-Control Studies
Confounding Factors (Epidemiology)
Incidence
PubMed
Cohort Studies
Language
Databases

Keywords

  • Diabetes
  • endometrial cancer
  • meta-analysis
  • Risk
  • Endometrial Cancer
  • Meta-analysis

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

Cite this

The effect of diabetes on the risk of endometrial Cancer : an updated a systematic review and meta-analysis. / Saed, Lotfolah; Varse, Fatemeh; Baradaran, Hamid Reza; Moradi, Yousef (Corresponding Author); Khateri, Sorour; Friberg, Emilie; Khazaei, Zaher; Gharahjeh, Saeedeh; Tehrani, Shahrzad; Sioofy-Khojine, Amir-Babak; Najmi, Zahra.

In: BMC Cancer, Vol. 19, 527, 31.05.2019.

Research output: Contribution to journalArticle

Saed, L, Varse, F, Baradaran, HR, Moradi, Y, Khateri, S, Friberg, E, Khazaei, Z, Gharahjeh, S, Tehrani, S, Sioofy-Khojine, A-B & Najmi, Z 2019, 'The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis', BMC Cancer, vol. 19, 527. https://doi.org/10.1186/s12885-019-5748-4
Saed, Lotfolah ; Varse, Fatemeh ; Baradaran, Hamid Reza ; Moradi, Yousef ; Khateri, Sorour ; Friberg, Emilie ; Khazaei, Zaher ; Gharahjeh, Saeedeh ; Tehrani, Shahrzad ; Sioofy-Khojine, Amir-Babak ; Najmi, Zahra. / The effect of diabetes on the risk of endometrial Cancer : an updated a systematic review and meta-analysis. In: BMC Cancer. 2019 ; Vol. 19.
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abstract = "BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95{\%} CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95{\%} CI 1.21-2.01), and it was 1.85 (95{\%} CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95{\%} CI 1.34-1.97).CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.",
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T1 - The effect of diabetes on the risk of endometrial Cancer

T2 - an updated a systematic review and meta-analysis

AU - Saed, Lotfolah

AU - Varse, Fatemeh

AU - Baradaran, Hamid Reza

AU - Moradi, Yousef

AU - Khateri, Sorour

AU - Friberg, Emilie

AU - Khazaei, Zaher

AU - Gharahjeh, Saeedeh

AU - Tehrani, Shahrzad

AU - Sioofy-Khojine, Amir-Babak

AU - Najmi, Zahra

N1 - Funding This research was funded by Systematic Review Network Center, Iran University of Medical Sciences (Grant Number 97–4–37-13922).

PY - 2019/5/31

Y1 - 2019/5/31

N2 - BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97).CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

AB - BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97).CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

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KW - Endometrial Cancer

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