The effect of dietary vitamin A on the immunocompetence of Atlantic salmon (Salmo salar L.)

I. Thompson*, T. C. Fletcher, D. F. Houlihan, C. J. Secombes

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Atlantic salmon, Salmo salar L. were maintained on diets containing low (0.37 mg kg-1 diet), normal (1.95 mg kg-1 diet) and high (15 mg kg-1 diet) levels of vitamin A fed at 1.5% body weight per day. After 4 months, liver vitamin A levels reflected dietary intake and growth rates of all three groups were similar. Kidney leucocyte migration and serum bactericidal activity were found to be significantly reduced in fish fed low levels of vitamin A. On the other hand, high levels of vitamin A in the diet were found to augment serum antiprotease activity relative to the levels found in the other dietary groups. However, phagocyte respiratory burst activity, bactericidal activity and eicosanoid production were unaffected by the dietary vitamin A regime, as were lymphocyte functions (lymphokine and antibody production) and both serum lysozyme and classical complement activity. That the overall immunomodulatory effect of vitamin A was small was reflected in the resistance to Aeromonas salmonicida. No significant differences were found between the different vitamin A intake groups despite a trend to decreased resistance in the low vitamin A diet group.

Original languageEnglish
Pages (from-to)513-523
Number of pages11
JournalFish Physiology and Biochemistry
Volume12
Issue number6
DOIs
Publication statusPublished - Mar 1994

Fingerprint

immunocompetence
Immunocompetence
Salmo salar
vitamin
Vitamin A
vitamin A
Nutrition
diet
Diet
serum
Serum
Aeromonas salmonicida
lymphokines
eicosanoids
Respiratory Burst
Lymphocytes
Eicosanoids
effect
Lymphokines
phagocytes

Keywords

  • Atlantic salmon
  • diet
  • immunity
  • vitamin A

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Aquatic Science

Cite this

The effect of dietary vitamin A on the immunocompetence of Atlantic salmon (Salmo salar L.). / Thompson, I.; Fletcher, T. C.; Houlihan, D. F.; Secombes, C. J.

In: Fish Physiology and Biochemistry, Vol. 12, No. 6, 03.1994, p. 513-523.

Research output: Contribution to journalArticle

Thompson, I. ; Fletcher, T. C. ; Houlihan, D. F. ; Secombes, C. J. / The effect of dietary vitamin A on the immunocompetence of Atlantic salmon (Salmo salar L.). In: Fish Physiology and Biochemistry. 1994 ; Vol. 12, No. 6. pp. 513-523.
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