TY - JOUR
T1 - The effect of L-thyroxine treatment on memory quotient in adults with subclinical hypothyroidism
T2 - A randomized double blind controlled trial
AU - Malek, M.
AU - Khamseh, M. E.
AU - Hadian, A.
AU - Baradaran, H. R.
AU - Emami, Z.
AU - Aghili, R.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Introduction: Verbal memory and executive function might be disturbed in subclinical hypothyroidism. The aim of this study was to explore the effect of levothyroxine treatment on the memory quotient of Anti-TPO-Ab positive subjects with subclinical hypothyroidism. Materials and Methods: Sixty Anti-Tpo-Ab positive subjects (51 female, 9 male) with subclinical hypothyroidism with a mean age of 34 were enrolled in this randomized double blind placebo controlled trial. Subjects were randomized into two groups, i.e. the case (26 females- 4 males) and the controls (25 females, 5 males) groups. Using the Weschler memory test, memory quotient was assessed at the beginning and three months after initiation of levothyroxine treatment. Results: The mean age of subjects was 34.22±10.75 y and the mean TSH level was 8.25±3.64 mIU/l. There was no difference between two groups in relation to the memory quotient at the beginning of the study (10.5.70±11.66 vs 105.87±11.49, P=0.83). Following treatment the mean for the memory quotient rose by 9.9±8.01 in the cases and 3.23±7.63 in the controls (P=0.002). Conclusion: In this study we observed an increase in the memory quotient after treatment with levothyroxine in individuals with subclinical hypothyroidism, demonstrating that levothyroxine treatment could be recommended to improve verbal memory and executive function in this group of subjects.
AB - Introduction: Verbal memory and executive function might be disturbed in subclinical hypothyroidism. The aim of this study was to explore the effect of levothyroxine treatment on the memory quotient of Anti-TPO-Ab positive subjects with subclinical hypothyroidism. Materials and Methods: Sixty Anti-Tpo-Ab positive subjects (51 female, 9 male) with subclinical hypothyroidism with a mean age of 34 were enrolled in this randomized double blind placebo controlled trial. Subjects were randomized into two groups, i.e. the case (26 females- 4 males) and the controls (25 females, 5 males) groups. Using the Weschler memory test, memory quotient was assessed at the beginning and three months after initiation of levothyroxine treatment. Results: The mean age of subjects was 34.22±10.75 y and the mean TSH level was 8.25±3.64 mIU/l. There was no difference between two groups in relation to the memory quotient at the beginning of the study (10.5.70±11.66 vs 105.87±11.49, P=0.83). Following treatment the mean for the memory quotient rose by 9.9±8.01 in the cases and 3.23±7.63 in the controls (P=0.002). Conclusion: In this study we observed an increase in the memory quotient after treatment with levothyroxine in individuals with subclinical hypothyroidism, demonstrating that levothyroxine treatment could be recommended to improve verbal memory and executive function in this group of subjects.
KW - Memory quotient
KW - Subclinical hypothyroidism
KW - Wechsler memory test
UR - http://www.scopus.com/inward/record.url?scp=84859396580&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84859396580
SN - 1683-4844
VL - 13
SP - 577
EP - 581
JO - Iranian Journal of Endocrinology and Metabolism
JF - Iranian Journal of Endocrinology and Metabolism
IS - 6
ER -