The Effect of Oligohydramnios on Tissue and Cellular Morphometry in the Developing Fetal Murine Lung

Tanbir Najrana, Juan Sanchez-Esteban, Rasha Abu Eid

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Mechanical forces play important roles in fetal lung development, therefore, pulmonary hypoplasia is an expected response to Oligohydramnios (OH) due to the decrease of fluid pressure. Amniotic sacs were punctured in pregnant mice with untouched fetuses serving as controls. Fetuses were delivered, and lung tissues collected. Histological sections were imaged and analyzed at the tissue level and the cellular level. Various morphometric descriptors of size, shape and differentiation were used to compare tissues from OH and untouched controls. Our results show that OH leads to smaller, less developed air spaces when compared to controls. Furthermore, cells from OH fetuses are smaller and less regular in shape compared to controls. There is also a defect in the differentiation of Type I alveolar epithelial cells. Here, we show a significant change in the morphometry of the fetal lung as a result of OH. These changes are consistent with the observed pulmonary hypoplasia and are important objective parameters that help in elucidating mechanisms of lung development and potential management of OH induced pulmonary hypoplasia.
Original languageEnglish
Title of host publication2017 21st International Conference on Control Systems and Computer Science (CSCS)
EditorsIoan Dumitrache, Adina Magda Florea, Florin Pop, Alexandru Dumitrașcu
Place of PublicationBucharest, Romania
PublisherIEEE Explore
Pages1-6
Number of pages6
ISBN (Print)9781538618400
DOIs
Publication statusPublished - 7 Jul 2017
Event21st International Conference on Control Systems and Computer Science (CSCS21) - Bucharest, Romania
Duration: 29 May 201731 May 2017

Conference

Conference21st International Conference on Control Systems and Computer Science (CSCS21)
CountryRomania
CityBucharest
Period29/05/1731/05/17

Keywords

  • Oligohydramnios
  • image analysis
  • morphometry
  • fractal dimension
  • pulmonary hypoplasia

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  • Cite this

    Najrana, T., Sanchez-Esteban, J., & Abu Eid, R. (2017). The Effect of Oligohydramnios on Tissue and Cellular Morphometry in the Developing Fetal Murine Lung. In I. Dumitrache, A. M. Florea, F. Pop, & A. Dumitrașcu (Eds.), 2017 21st International Conference on Control Systems and Computer Science (CSCS) (pp. 1-6). IEEE Explore. https://doi.org/10.1109/CSCS.2017.52