The effectiveness of inhaled corticosteroid therapy in preschool children with asthma

a systematic review of literature

D. Enting, S. Schokker, E. J. Duiverman, Thys Van Der Molen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective
To evaluate the effectiveness of inhaled corticosteroid therapy in
asthmatic children in the age group of 0-6 years.
Study design
Systematic review of randomised double blind placebo controlled
trials of inhaled corticosteroid therapy for preschool children with
asthma. 12 Trials were identified for this review. Data on symptom
scores, parents' sleep disturbance, parents' assessment of asthma
status/medication, concomitant drug use, exacerbation rate, lung
function measurement, and adverse effects were retrieved form the
trials.
Results
Most parallel trials showed significant improvements in symptom
scores, concomitant drug use, exacerbation rate, or lung function
measurements. Most improvements were seen in wheeze and
concomitant drug use. The pooled odds ratio (95% confidence
interval (CI)) for outcome measure 'patients with at least one
exacerbation' was 0.47 (0.3 to 0.73). Two crossover trials showed
significant improvements in symptom scores, ß-agonist use, and lung
function. Significant differences in adverse effects between the
active and placebo groups were not detected.
Conclusion
In conclusion, this systematic review of literature shows beneficial
effects on symptoms, exacerbation rate, and pulmonary function for
the use of inhaled corticosteroids in preschool children with asthma.
Original languageEnglish
Pages (from-to)52-57
Number of pages5
JournalPrimary Care Respiratory Journal
Volume12
Issue number2
Publication statusPublished - 2003

Fingerprint

Preschool Children
Adrenal Cortex Hormones
Asthma
Parents
Placebos
Pharmaceutical Preparations
Lung
Cross-Over Studies
Sleep
Therapeutics
Age Groups
Odds Ratio
Outcome Assessment (Health Care)

Cite this

The effectiveness of inhaled corticosteroid therapy in preschool children with asthma : a systematic review of literature. / Enting, D.; Schokker, S.; Duiverman, E. J.; Van Der Molen, Thys.

In: Primary Care Respiratory Journal, Vol. 12, No. 2, 2003, p. 52-57.

Research output: Contribution to journalArticle

Enting, D. ; Schokker, S. ; Duiverman, E. J. ; Van Der Molen, Thys. / The effectiveness of inhaled corticosteroid therapy in preschool children with asthma : a systematic review of literature. In: Primary Care Respiratory Journal. 2003 ; Vol. 12, No. 2. pp. 52-57.
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abstract = "Objective To evaluate the effectiveness of inhaled corticosteroid therapy in asthmatic children in the age group of 0-6 years. Study design Systematic review of randomised double blind placebo controlled trials of inhaled corticosteroid therapy for preschool children with asthma. 12 Trials were identified for this review. Data on symptom scores, parents' sleep disturbance, parents' assessment of asthma status/medication, concomitant drug use, exacerbation rate, lung function measurement, and adverse effects were retrieved form the trials. Results Most parallel trials showed significant improvements in symptom scores, concomitant drug use, exacerbation rate, or lung function measurements. Most improvements were seen in wheeze and concomitant drug use. The pooled odds ratio (95{\%} confidence interval (CI)) for outcome measure 'patients with at least one exacerbation' was 0.47 (0.3 to 0.73). Two crossover trials showed significant improvements in symptom scores, {\ss}-agonist use, and lung function. Significant differences in adverse effects between the active and placebo groups were not detected. Conclusion In conclusion, this systematic review of literature shows beneficial effects on symptoms, exacerbation rate, and pulmonary function for the use of inhaled corticosteroids in preschool children with asthma.",
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N2 - Objective To evaluate the effectiveness of inhaled corticosteroid therapy in asthmatic children in the age group of 0-6 years. Study design Systematic review of randomised double blind placebo controlled trials of inhaled corticosteroid therapy for preschool children with asthma. 12 Trials were identified for this review. Data on symptom scores, parents' sleep disturbance, parents' assessment of asthma status/medication, concomitant drug use, exacerbation rate, lung function measurement, and adverse effects were retrieved form the trials. Results Most parallel trials showed significant improvements in symptom scores, concomitant drug use, exacerbation rate, or lung function measurements. Most improvements were seen in wheeze and concomitant drug use. The pooled odds ratio (95% confidence interval (CI)) for outcome measure 'patients with at least one exacerbation' was 0.47 (0.3 to 0.73). Two crossover trials showed significant improvements in symptom scores, ß-agonist use, and lung function. Significant differences in adverse effects between the active and placebo groups were not detected. Conclusion In conclusion, this systematic review of literature shows beneficial effects on symptoms, exacerbation rate, and pulmonary function for the use of inhaled corticosteroids in preschool children with asthma.

AB - Objective To evaluate the effectiveness of inhaled corticosteroid therapy in asthmatic children in the age group of 0-6 years. Study design Systematic review of randomised double blind placebo controlled trials of inhaled corticosteroid therapy for preschool children with asthma. 12 Trials were identified for this review. Data on symptom scores, parents' sleep disturbance, parents' assessment of asthma status/medication, concomitant drug use, exacerbation rate, lung function measurement, and adverse effects were retrieved form the trials. Results Most parallel trials showed significant improvements in symptom scores, concomitant drug use, exacerbation rate, or lung function measurements. Most improvements were seen in wheeze and concomitant drug use. The pooled odds ratio (95% confidence interval (CI)) for outcome measure 'patients with at least one exacerbation' was 0.47 (0.3 to 0.73). Two crossover trials showed significant improvements in symptom scores, ß-agonist use, and lung function. Significant differences in adverse effects between the active and placebo groups were not detected. Conclusion In conclusion, this systematic review of literature shows beneficial effects on symptoms, exacerbation rate, and pulmonary function for the use of inhaled corticosteroids in preschool children with asthma.

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