The effectiveness of national influenza vaccination policies for at-risk populations over 5 seasons in a Scottish general practice

V. Sivaprakasam, J. Douglas, Sivasubramaniam Selvaraj, S. Macintyre, W. F. Carman

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Aim: To determine the effectiveness of serial influenza vaccination.

    Scope: Studied in a Scottish GP population, the overall seroresponse rate increased with annual influenza vaccinations and after 5 years it increased from 45.1% to 93.3% for influenza virus A (H1) and from 48.4% to 98.3% for influenza virus A (H3). However, there was little boosting effect with further doses after becoming a seroresponder. The pre-vaccination titres were significantly higher in previous year's seroresponders compared to non-responders.

    Conclusions: The policy of annual vaccination is supported by our data in order to increase the disappointing response rate after one dose. However, the lack of a boosting response with subsequent doses and the significant residual immunity after becoming a seroresponder suggests a prior serological immunity check in order to better direct the vaccine supply (in the years of no antigenic drift), to those who need it most. (C) 2008 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)3772-3777
    Number of pages5
    JournalVaccine
    Volume26
    Issue number29-30
    DOIs
    Publication statusPublished - Jul 2008

    Keywords

    • influenza
    • vaccination
    • seroresponders
    • immune-response
    • elderly-people
    • controlled-trial
    • working adults
    • virus vaccine
    • efficacy
    • healthy
    • immunization
    • epidemic
    • strain

    Cite this

    The effectiveness of national influenza vaccination policies for at-risk populations over 5 seasons in a Scottish general practice. / Sivaprakasam, V.; Douglas, J.; Selvaraj, Sivasubramaniam; Macintyre, S.; Carman, W. F.

    In: Vaccine, Vol. 26, No. 29-30, 07.2008, p. 3772-3777.

    Research output: Contribution to journalArticle

    Sivaprakasam, V. ; Douglas, J. ; Selvaraj, Sivasubramaniam ; Macintyre, S. ; Carman, W. F. / The effectiveness of national influenza vaccination policies for at-risk populations over 5 seasons in a Scottish general practice. In: Vaccine. 2008 ; Vol. 26, No. 29-30. pp. 3772-3777.
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    abstract = "Aim: To determine the effectiveness of serial influenza vaccination.Scope: Studied in a Scottish GP population, the overall seroresponse rate increased with annual influenza vaccinations and after 5 years it increased from 45.1{\%} to 93.3{\%} for influenza virus A (H1) and from 48.4{\%} to 98.3{\%} for influenza virus A (H3). However, there was little boosting effect with further doses after becoming a seroresponder. The pre-vaccination titres were significantly higher in previous year's seroresponders compared to non-responders.Conclusions: The policy of annual vaccination is supported by our data in order to increase the disappointing response rate after one dose. However, the lack of a boosting response with subsequent doses and the significant residual immunity after becoming a seroresponder suggests a prior serological immunity check in order to better direct the vaccine supply (in the years of no antigenic drift), to those who need it most. (C) 2008 Elsevier Ltd. All rights reserved.",
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    AU - Douglas, J.

    AU - Selvaraj, Sivasubramaniam

    AU - Macintyre, S.

    AU - Carman, W. F.

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    AB - Aim: To determine the effectiveness of serial influenza vaccination.Scope: Studied in a Scottish GP population, the overall seroresponse rate increased with annual influenza vaccinations and after 5 years it increased from 45.1% to 93.3% for influenza virus A (H1) and from 48.4% to 98.3% for influenza virus A (H3). However, there was little boosting effect with further doses after becoming a seroresponder. The pre-vaccination titres were significantly higher in previous year's seroresponders compared to non-responders.Conclusions: The policy of annual vaccination is supported by our data in order to increase the disappointing response rate after one dose. However, the lack of a boosting response with subsequent doses and the significant residual immunity after becoming a seroresponder suggests a prior serological immunity check in order to better direct the vaccine supply (in the years of no antigenic drift), to those who need it most. (C) 2008 Elsevier Ltd. All rights reserved.

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    KW - controlled-trial

    KW - working adults

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    KW - healthy

    KW - immunization

    KW - epidemic

    KW - strain

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