TY - JOUR
T1 - The effectiveness of Paraffin oil and Mineral oil for day-5 embryo culture in couples undergoing in vitro fertilisation
AU - Pham, Huy H.
AU - Dang, Quyen T.
AU - Nguyen, Hue N.
AU - Tran, Cam T.
AU - Pham, Quan T.
AU - Mol, Ben W.
AU - Dang, Vinh Q.
N1 - Funding Information:
This study was funded by My Duc Hospital, Ho Chi Minh City, Viet Nam.
PY - 2022/8
Y1 - 2022/8
N2 - Objective: This study evaluated the effectiveness of Paraffin oil versus Mineral oil for day-5 embryo culture in couples undergoing assisted reproductive technology (ART). Methods: We performed a multi-centre, retrospective cohort study at IVFMD (My Duc Hospital) and IVFMD Phu Nhuan (My Duc Phu Nhuan Hospital) from January 2019 to September 2019. We studied couples treated by intracytoplasmic sperm injection (ICSI), using fresh, ejaculated semen and undergoing day-5 embryo transfer. Couples who underwent in vitro maturation (IVM) or oocyte donation cycles or couples where the woman had uterine abnormalities were excluded. From January 2019 to May 2019, we used Mineral oil (LiteOil, LifeGlobal) while Paraffin oil (Liquid Paraffin, Origio) was used from June 2019 to September 2019. The primary outcome was live birth rate after the first transfer, either from a fresh transfer or frozen embryo transfer. Results: Between 1st January 2019 to 30th September 2019, there were 2,312 couples undergoing ART in both centres, of which 762 (377 in the Paraffin group and 385 in the Mineral group) eligible couples were included in the study. Baseline characteristics of couples were comparable between the two groups, with mean female age 31.5 ± 4.3 versus 31.9 ± 4.7 in the Paraffin and Mineral group. Live birth after the first transfer occurred in 153 (40.6%) couples in the Paraffin group, compared to 152 (39.5%) couples in the Mineral group (risk ratio 1.02, 95% confidence interval 0.91 – 1.14). Other secondary outcomes were comparable between the two groups. Conclusion: In day-5 embryo culture, Paraffin and Mineral oil resulted in a comparable live birth rate.
AB - Objective: This study evaluated the effectiveness of Paraffin oil versus Mineral oil for day-5 embryo culture in couples undergoing assisted reproductive technology (ART). Methods: We performed a multi-centre, retrospective cohort study at IVFMD (My Duc Hospital) and IVFMD Phu Nhuan (My Duc Phu Nhuan Hospital) from January 2019 to September 2019. We studied couples treated by intracytoplasmic sperm injection (ICSI), using fresh, ejaculated semen and undergoing day-5 embryo transfer. Couples who underwent in vitro maturation (IVM) or oocyte donation cycles or couples where the woman had uterine abnormalities were excluded. From January 2019 to May 2019, we used Mineral oil (LiteOil, LifeGlobal) while Paraffin oil (Liquid Paraffin, Origio) was used from June 2019 to September 2019. The primary outcome was live birth rate after the first transfer, either from a fresh transfer or frozen embryo transfer. Results: Between 1st January 2019 to 30th September 2019, there were 2,312 couples undergoing ART in both centres, of which 762 (377 in the Paraffin group and 385 in the Mineral group) eligible couples were included in the study. Baseline characteristics of couples were comparable between the two groups, with mean female age 31.5 ± 4.3 versus 31.9 ± 4.7 in the Paraffin and Mineral group. Live birth after the first transfer occurred in 153 (40.6%) couples in the Paraffin group, compared to 152 (39.5%) couples in the Mineral group (risk ratio 1.02, 95% confidence interval 0.91 – 1.14). Other secondary outcomes were comparable between the two groups. Conclusion: In day-5 embryo culture, Paraffin and Mineral oil resulted in a comparable live birth rate.
KW - Embryo culture
KW - Live birth rate
KW - Mineral oil
KW - Paraffin oil
UR - http://www.scopus.com/inward/record.url?scp=85132719541&partnerID=8YFLogxK
UR - https://aspire2021.cme-congresses.com/wp-content/uploads/2021/04/3.7-574282.pdf
U2 - 10.1016/j.ejogrb.2022.06.014
DO - 10.1016/j.ejogrb.2022.06.014
M3 - Article
C2 - 35749967
AN - SCOPUS:85132719541
VL - 275
SP - 59
EP - 63
JO - European Journal of Obstetrics & Gynecology and Reproductive Biology
JF - European Journal of Obstetrics & Gynecology and Reproductive Biology
SN - 0301-2115
T2 - The 10th Congress of the Asia Pacific Initiative on Reproduction
Y2 - 30 April 2021 through 2 May 2021
ER -