The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects

F Khan, K Elherik, Caroline Bolton-Smith, Rebecca Barr, A Hill, I Murrie, J J F Belch

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

objective: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. Methods: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil. and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. Results: Acetylcholine. but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. Conclusions: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6% in eicosapentaenoic acid and 27% in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)955-962
Number of pages8
JournalCardiovascular Research
Volume59
Issue number4
DOIs
Publication statusPublished - 1 Oct 2003

Keywords

  • acetylcholine
  • endothelial function
  • microcirculation
  • nitric oxide
  • vasoconstriction/dilation
  • CORONARY HEART-DISEASE
  • FOOD-FREQUENCY QUESTIONNAIRE
  • CARDIOVASCULAR-DISEASE
  • DEPENDENT VASODILATION
  • RHEUMATOID-ARTHRITIS
  • FISH CONSUMPTION
  • IN-VITRO
  • N-3
  • HYPERCHOLESTEROLEMIA
  • MICROCIRCULATION
  • Acetylcholine
  • Endothelial function
  • Microcirculation
  • Nitric oxide
  • Vasoconstriction/dilation

Cite this

The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. / Khan, F ; Elherik, K ; Bolton-Smith, Caroline; Barr, Rebecca; Hill, A ; Murrie, I ; Belch, J J F .

In: Cardiovascular Research, Vol. 59, No. 4, 01.10.2003, p. 955-962.

Research output: Contribution to journalArticle

Khan, F, Elherik, K, Bolton-Smith, C, Barr, R, Hill, A, Murrie, I & Belch, JJF 2003, 'The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects', Cardiovascular Research, vol. 59, no. 4, pp. 955-962. https://doi.org/10.1016/S0008-6363(03)00395-X
Khan, F ; Elherik, K ; Bolton-Smith, Caroline ; Barr, Rebecca ; Hill, A ; Murrie, I ; Belch, J J F . / The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. In: Cardiovascular Research. 2003 ; Vol. 59, No. 4. pp. 955-962.
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abstract = "objective: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. Methods: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil. and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. Results: Acetylcholine. but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. Conclusions: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6{\%} in eicosapentaenoic acid and 27{\%} in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.",
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T1 - The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects

AU - Khan, F

AU - Elherik, K

AU - Bolton-Smith, Caroline

AU - Barr, Rebecca

AU - Hill, A

AU - Murrie, I

AU - Belch, J J F

PY - 2003/10/1

Y1 - 2003/10/1

N2 - objective: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. Methods: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil. and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. Results: Acetylcholine. but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. Conclusions: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6% in eicosapentaenoic acid and 27% in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

AB - objective: Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years. Methods: In a double-blind, randomised, placebo controlled study, 173 healthy volunteers took one of six oil supplements for 8 months. Supplements were placebo, oleic acid rich sunflower oil, evening primrose oil, soya bean oil, tuna fish oil. and tuna/evening primrose oil mix. Endothelium-dependent and independent vascular responses were measured in the forearm skin using laser Doppler imaging following iontophoretic applications of acetylcholine and sodium nitroprusside, respectively. Results: Acetylcholine. but not sodium nitroprusside responses were significantly improved after tuna oil supplementation (P=0.02). Additionally, there were significant positive correlations between acetylcholine responses and n-3 fatty acid levels in the plasma and erythrocyte membrane phospholipids after tuna oil supplementation. No significant changes in vascular response were seen after supplementation with any of the other oils. Conclusions: Fish oil supplementation has a beneficial effect on endothelial function, even in normal healthy subjects. Modification of the diet by an increase of 6% in eicosapentaenoic acid and 27% in docosahexaenoic acid (equivalent to eating oily fish 2-3 times/week) might have significant beneficial effects on cardiovascular function and health. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

KW - acetylcholine

KW - endothelial function

KW - microcirculation

KW - nitric oxide

KW - vasoconstriction/dilation

KW - CORONARY HEART-DISEASE

KW - FOOD-FREQUENCY QUESTIONNAIRE

KW - CARDIOVASCULAR-DISEASE

KW - DEPENDENT VASODILATION

KW - RHEUMATOID-ARTHRITIS

KW - FISH CONSUMPTION

KW - IN-VITRO

KW - N-3

KW - HYPERCHOLESTEROLEMIA

KW - MICROCIRCULATION

KW - Acetylcholine

KW - Endothelial function

KW - Microcirculation

KW - Nitric oxide

KW - Vasoconstriction/dilation

U2 - 10.1016/S0008-6363(03)00395-X

DO - 10.1016/S0008-6363(03)00395-X

M3 - Article

VL - 59

SP - 955

EP - 962

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 4

ER -