The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Luigi Fontana; Sharon E Mitchell; Boshi Wang; Valeria Tosti; Thijmen van Vliet; Nicola Veronese; Beatrice Bertozzi; Dayna S Early; Parcival Maissan; John R Speakman; Marco Demaria

doi:10.1111/acel.12746

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Luigi Fontana, Sharon E Mitchell, Boshi Wang, Valeria Tosti, Thijmen van Vliet, Nicola Veronese, Beatrice Bertozzi, Dayna S Early, Parcival Maissan, John R Speakman, Marco Demaria

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Abstract

Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle-age human volunteers under CR in comparison with age-matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.

Original language	English
Article number	e12746
Journal	Aging Cell
Volume	17
Issue number	3
Early online date	25 Mar 2018
DOIs	https://doi.org/10.1111/acel.12746
Publication status	Published - Jun 2018

Bibliographical note

Funding information: National Center for Research Resources, Grant/Award Number: UL1 RR024992; National Natural Science Foundation of China, Grant/Award Number: 91649108; Biotechnology and Biological Sciences
Research Council, Grant/Award Number: G009953/1; Bakewell Foundation; Longer
Life Foundation

ACKNOWLEDGMENTS: The mouse work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK (Standard Grant BB/
G009953/1 and a China partnering award (BB/JO20028/1) plus an award from the National Science Foundation of China (NSFC: Aging initiative: grant reference number 91649108). Human work was supported by grants from the Bakewell Foundation, the Longer Life Foundation (an RGA/Washington University Partnership), and the National Center for Research Resources (UL1 RR024992). The funding agencies had no role in the analysis or interpretation of the data
or in the decision to submit the report for publication. The authors declare no competing financial interests.

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/acel.12746Licence: CC BY

The effects of graded caloric restriction
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Final published version, 576 KBLicence: CC BY

Cite this

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abstract = "Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle-age human volunteers under CR in comparison with age-matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.",

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note = "Funding information: National Center for Research Resources, Grant/Award Number: UL1 RR024992; National Natural Science Foundation of China, Grant/Award Number: 91649108; Biotechnology and Biological Sciences Research Council, Grant/Award Number: G009953/1; Bakewell Foundation; Longer Life Foundation ACKNOWLEDGMENTS: The mouse work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK (Standard Grant BB/ G009953/1 and a China partnering award (BB/JO20028/1) plus an award from the National Science Foundation of China (NSFC: Aging initiative: grant reference number 91649108). Human work was supported by grants from the Bakewell Foundation, the Longer Life Foundation (an RGA/Washington University Partnership), and the National Center for Research Resources (UL1 RR024992). The funding agencies had no role in the analysis or interpretation of the data or in the decision to submit the report for publication. The authors declare no competing financial interests.",

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AU - van Vliet, Thijmen

AU - Veronese, Nicola

AU - Bertozzi, Beatrice

AU - Early, Dayna S

AU - Maissan, Parcival

AU - Speakman, John R

AU - Demaria, Marco

N1 - Funding information: National Center for Research Resources, Grant/Award Number: UL1 RR024992; National Natural Science Foundation of China, Grant/Award Number: 91649108; Biotechnology and Biological Sciences Research Council, Grant/Award Number: G009953/1; Bakewell Foundation; Longer Life Foundation ACKNOWLEDGMENTS: The mouse work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK (Standard Grant BB/ G009953/1 and a China partnering award (BB/JO20028/1) plus an award from the National Science Foundation of China (NSFC: Aging initiative: grant reference number 91649108). Human work was supported by grants from the Bakewell Foundation, the Longer Life Foundation (an RGA/Washington University Partnership), and the National Center for Research Resources (UL1 RR024992). The funding agencies had no role in the analysis or interpretation of the data or in the decision to submit the report for publication. The authors declare no competing financial interests.

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The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Abstract

Bibliographical note

Keywords

UN SDGs

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