The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Luigi Fontana, Sharon E Mitchell, Boshi Wang, Valeria Tosti, Thijmen van Vliet, Nicola Veronese, Beatrice Bertozzi, Dayna S Early, Parcival Maissan, John R Speakman, Marco Demaria

Research output: Contribution to journalArticle

10 Citations (Scopus)
7 Downloads (Pure)

Abstract

Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle-age human volunteers under CR in comparison with age-matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.

Original languageEnglish
Article numbere12746
JournalAging Cell
Volume17
Issue number3
Early online date25 Mar 2018
DOIs
Publication statusPublished - Jun 2018

    Fingerprint

Keywords

  • Journal Article

Cite this