The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

David Lusseau, Sharon E. Mitchell, Ceres Barros, Davina Derous, Cara Green, Luonan Chen, Jing-Dong Jackie Han, Yingchun Wang, Daniel E. L. Promislow, Alexander Douglas, John R. Speakman

Research output: Contribution to journalArticle

15 Citations (Scopus)
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Abstract

Animals have to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy intake. If CR is pronounced, allostasis can push individuals into alternate physiological states which can result in important health benefits across a wide range of taxa. Here we developed a new approach to determine the changes in behavioural phenotype associated with different levels of CR. We exposed C57BL/6 male mice to graded CR (from 0 to 40%) for three months and defined their behavioural phenotype using hidden Markov models of their movement and body temperature. All 40% CR mice exhibited a state-shift in behavioural phenotype and only some exposed to 30% CR did. We show for the first time that mice changed their activity characteristics rather than changed their activities. This new phenotyping approach provides an avenue to determine the mechanisms linking CR to healthspan.
Original languageEnglish
Article number13198
Number of pages12
JournalScientific Reports
Volume5
Early online date25 Aug 2015
DOIs
Publication statusPublished - 25 Aug 2015

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