The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

David Lusseau; Sharon E. Mitchell; Ceres Barros; Davina Derous; Cara  Green; Luonan Chen; Jing-Dong Jackie Han; Yingchun Wang; Daniel E. L. Promislow; Alexander Douglas; John R. Speakman

doi:10.1038/srep13198

The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

David Lusseau, Sharon E. Mitchell, Ceres Barros, Davina Derous, Cara Green, Luonan Chen, Jing-Dong Jackie Han, Yingchun Wang, Daniel E. L. Promislow, Alexander Douglas, John R. Speakman

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Abstract

Animals have to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy intake. If CR is pronounced, allostasis can push individuals into alternate physiological states which can result in important health benefits across a wide range of taxa. Here we developed a new approach to determine the changes in behavioural phenotype associated with different levels of CR. We exposed C57BL/6 male mice to graded CR (from 0 to 40%) for three months and defined their behavioural phenotype using hidden Markov models of their movement and body temperature. All 40% CR mice exhibited a state-shift in behavioural phenotype and only some exposed to 30% CR did. We show for the first time that mice changed their activity characteristics rather than changed their activities. This new phenotyping approach provides an avenue to determine the mechanisms linking CR to healthspan.

Original language	English
Article number	13198
Number of pages	12
Journal	Scientific Reports
Volume	5
Early online date	25 Aug 2015
DOIs	https://doi.org/10.1038/srep13198
Publication status	Published - 25 Aug 2015

Bibliographical note

We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (BB/G009953/1 and BB/J020028/1).

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The effects of graded levels of calorie restriction
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Lusseau, D., Mitchell, S. E., Barros, C., Derous, D., Green, C., Chen, L., Han, J.-D. J., Wang, Y., Promislow, D. E. L., Douglas, A., & Speakman, J. R. (2015). The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction. Scientific Reports, 5, Article 13198 . https://doi.org/10.1038/srep13198

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abstract = "Animals have to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy intake. If CR is pronounced, allostasis can push individuals into alternate physiological states which can result in important health benefits across a wide range of taxa. Here we developed a new approach to determine the changes in behavioural phenotype associated with different levels of CR. We exposed C57BL/6 male mice to graded CR (from 0 to 40%) for three months and defined their behavioural phenotype using hidden Markov models of their movement and body temperature. All 40% CR mice exhibited a state-shift in behavioural phenotype and only some exposed to 30% CR did. We show for the first time that mice changed their activity characteristics rather than changed their activities. This new phenotyping approach provides an avenue to determine the mechanisms linking CR to healthspan.",

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The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

Abstract

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