The effects of graded levels of calorie restriction: VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

Sharon E Mitchell, Zhan Hui Tang, Celine Kerbois, Camille Delville, Davina Derous, Cara L Green, Yingchun Wang, Jackie J D Han, Luonan Chen, Alex Douglas, David Lusseau, Daniel E L Promislow, John R Speakman

Research output: Contribution to journalArticle

11 Citations (Scopus)
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Abstract

Under calorie restriction (CR) animals need to lower energy demands. Whether this involves a reduction in cellular metabolism is an issue of contention. We exposed C57BL/6 mice to graded CR for 3 months, measured BMR and dissected out 20 body compartments. From a separate age-matched group (n=57), we built 7 predictive models for BMR. Unadjusted BMR declined with severity of restriction. Comparison of measured and predicted BMR from the simple models suggested suppression occurred. The extent of 'suppression' was greater with increased CR severity. However, when models based on individual organ sizes as predictors were used, the discrepancy between the prediction and the observed BMR disappeared. This suggested 'metabolic suppression' was an artefact of not having a detailed enough model to predict the expected changes in metabolism. Our data have wide implications because they indicate that inferred 'metabolic' impacts of genetic and other manipulations may reflect effects on organ morphology.

Original languageEnglish
Pages (from-to)17453-17474
Number of pages22
JournalOncotarget
Volume8
Issue number11
Early online date11 Feb 2017
DOIs
Publication statusPublished - 2017

Keywords

  • metabolic rate
  • dietary restriction
  • protein restriction
  • calorie restriction
  • metabolic suppression
  • Gerotarget

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