The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Deshun Sun* (Corresponding Author), Fei Liu, Sharon E Mitchell, Huanfei Ma, Davina Derous, Yingchun Wang, Jackie J.D. Han, Promislow, Daniel E.L., David Lusseau, Alex Douglas, John R Speakman, Luonan Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.
Original languageEnglish
Pages (from-to)858-866
Number of pages9
JournalThe Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Volume75
Issue number5
Early online date4 Mar 2020
DOIs
Publication statusPublished - May 2020

Keywords

  • calorie restriction
  • phase space reconstruction
  • attractors
  • gene expression
  • Phase space reconstruction
  • Calorie restriction
  • Attractors
  • Gene expression
  • MORTALITY
  • PROTEIN RESTRICTION
  • BODY-TEMPERATURE
  • KOLMOGOROV-ENTROPY
  • TRANSCRIPTOMIC RESPONSES
  • IMPACT
  • SHORT-TERM CALORIE
  • TIME-SERIES
  • PHYSICAL-ACTIVITY
  • LIFE

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Ageing

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