The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Deshun Sun* (Corresponding Author), Fei Liu, Sharon E Mitchell, Huanfei Ma, Davina Derous, Yingchun Wang, Jackie J.D. Han, Promislow, Daniel E.L., David Lusseau, Alex Douglas, John R Speakman, Luonan Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.
Original languageEnglish
JournalThe Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Early online date4 Mar 2020
DOIs
Publication statusE-pub ahead of print - 4 Mar 2020

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Keywords

  • calorie restriction
  • phase space reconstruction
  • attractors
  • gene expression

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