The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Deshun Sun; Fei Liu; Sharon E Mitchell; Huanfei Ma; Davina Derous; Yingchun Wang; Jackie J.D. Han; Promislow, Daniel E.L.; David Lusseau; Alex Douglas; John R Speakman; Luonan Chen

doi:10.1093/gerona/glaa055

The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

Deshun Sun^* (Corresponding Author), Fei Liu, Sharon E Mitchell, Huanfei Ma, Davina Derous, Yingchun Wang, Jackie J.D. Han, Promislow, Daniel E.L., David Lusseau, Alex Douglas, John R Speakman, Luonan Chen

^*Corresponding author for this work

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Abstract

Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.

Original language	English
Pages (from-to)	858-866
Number of pages	9
Journal	The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Volume	75
Issue number	5
Early online date	4 Mar 2020
DOIs	https://doi.org/10.1093/gerona/glaa055
Publication status	Published - May 2020

Keywords

calorie restriction
phase space reconstruction
attractors
gene expression
Phase space reconstruction
Calorie restriction
Attractors
Gene expression
MORTALITY
PROTEIN RESTRICTION
BODY-TEMPERATURE
KOLMOGOROV-ENTROPY
TRANSCRIPTOMIC RESPONSES
IMPACT
SHORT-TERM CALORIE
TIME-SERIES
PHYSICAL-ACTIVITY
LIFE

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This is a pre-copyedited, author-produced version of an article accepted for publication in Journals of Gerontology, Series A following peer review. The version of record Deshun Sun, PhD, Fei Liu, PhD, Sharon E Mitchell, PhD, Huanfei Ma, PhD, Davina Derous, PhD, Yingchun Wang, PhD, Jackie J D Han, PhD, Daniel E L Promislow, PhD, David Lusseau, PhD, Alex Douglas, PhD, John R Speakman, PhD, Luonan Chen, PhD, The Effects of Graded Levels of Calorie Restriction XV: Phase Space Attractors Reveal Distinct Behavioral Phenotypes, The Journals of Gerontology: Series A, Volume 75, Issue 5, May 2020, Pages 858–866, is available online at: https://academic.oup.com/biomedgerontology/article/75/5/858/5780099 or https://doi.org/10.1093/gerona/glaa055
Accepted author manuscript, 349 KBLicence: Unspecified

Cite this

Sun, D., Liu, F., Mitchell, S. E., Ma, H., Derous, D., Wang, Y., Han, J. J. D., Daniel E.L., P., Lusseau, D., Douglas, A., Speakman, J. R., & Chen, L. (2020). The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 75(5), 858-866. https://doi.org/10.1093/gerona/glaa055

The effects of graded levels of calorie restriction XV : phase space attractors reveal distinct behavioral phenotypes. / Sun, Deshun (Corresponding Author); Liu, Fei; Mitchell, Sharon E et al.

In: The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, Vol. 75, No. 5, 05.2020, p. 858-866.

Research output: Contribution to journal › Article › peer-review

Sun, D, Liu, F, Mitchell, SE, Ma, H, Derous, D, Wang, Y, Han, JJD, Daniel E.L., P, Lusseau, D , Douglas, A , Speakman, JR & Chen, L 2020, 'The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes', The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 5, pp. 858-866. https://doi.org/10.1093/gerona/glaa055

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abstract = "Calorie restriction (CR) has a positive impact on health and lifespan. Previous work however does not reveal the whole underlying mechanism of bahavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the bahavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90 day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE) and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.",

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The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

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The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

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