The effects of renal variation upon measurements of perfusion and leakage volume in breast tumours

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Abstract

Dynamic contrast enhanced MRI (DCE-MRI) and pharmacokinetic models have been used to measure tumour permeability (K-trans) and leakage volume (v(e)) in numerous studies. The construction of pharmacokinetic models describing such tissue properties relies on defining the blood plasma concentration of contrast agent with respect to time (C-p(t)). When direct measurement is not possible a bi-exponential decay has been applied using data from healthy volunteers. This work investigates, by simulation, the magnitude of errors resulting from this definition with respect to normal variation in renal function and for cases with renal impairment. Errors up to 23% in v(e) and 28% in K-trans were found for the normal simulations, and 67% in v(e) and 61% in K-trans for the impaired simulations. If this bi-exponential curve is used as an input function to the generalized kinetic model and used in oncology, estimates of tissue permeability and leakage volume will possess large errors due to variation in C-p(t) curves between subjects.

Original languageEnglish
Pages (from-to)2041-2051
Number of pages10
JournalPhysics in Medicine and Biology
Volume49
Issue number10
DOIs
Publication statusPublished - May 2004

Keywords

  • BRAIN-BARRIER PERMEABILITY
  • CONTRAST AGENT UPTAKE
  • GD-DTPA ENHANCEMENT
  • TRACER KINETICS
  • DYNAMIC MRI
  • PARAMETERS
  • MODEL
  • PHARMACOKINETICS
  • INJECTION
  • CONSTANT

Cite this

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title = "The effects of renal variation upon measurements of perfusion and leakage volume in breast tumours",
abstract = "Dynamic contrast enhanced MRI (DCE-MRI) and pharmacokinetic models have been used to measure tumour permeability (K-trans) and leakage volume (v(e)) in numerous studies. The construction of pharmacokinetic models describing such tissue properties relies on defining the blood plasma concentration of contrast agent with respect to time (C-p(t)). When direct measurement is not possible a bi-exponential decay has been applied using data from healthy volunteers. This work investigates, by simulation, the magnitude of errors resulting from this definition with respect to normal variation in renal function and for cases with renal impairment. Errors up to 23{\%} in v(e) and 28{\%} in K-trans were found for the normal simulations, and 67{\%} in v(e) and 61{\%} in K-trans for the impaired simulations. If this bi-exponential curve is used as an input function to the generalized kinetic model and used in oncology, estimates of tissue permeability and leakage volume will possess large errors due to variation in C-p(t) curves between subjects.",
keywords = "BRAIN-BARRIER PERMEABILITY, CONTRAST AGENT UPTAKE, GD-DTPA ENHANCEMENT, TRACER KINETICS, DYNAMIC MRI, PARAMETERS, MODEL, PHARMACOKINETICS, INJECTION, CONSTANT",
author = "Ahearn, {Trevor Sean} and Staff, {Roger T} and Redpath, {Thomas William} and Semple, {Scott Ian Kay}",
year = "2004",
month = "5",
doi = "10.1088/0031-9155/49/10/014",
language = "English",
volume = "49",
pages = "2041--2051",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
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TY - JOUR

T1 - The effects of renal variation upon measurements of perfusion and leakage volume in breast tumours

AU - Ahearn, Trevor Sean

AU - Staff, Roger T

AU - Redpath, Thomas William

AU - Semple, Scott Ian Kay

PY - 2004/5

Y1 - 2004/5

N2 - Dynamic contrast enhanced MRI (DCE-MRI) and pharmacokinetic models have been used to measure tumour permeability (K-trans) and leakage volume (v(e)) in numerous studies. The construction of pharmacokinetic models describing such tissue properties relies on defining the blood plasma concentration of contrast agent with respect to time (C-p(t)). When direct measurement is not possible a bi-exponential decay has been applied using data from healthy volunteers. This work investigates, by simulation, the magnitude of errors resulting from this definition with respect to normal variation in renal function and for cases with renal impairment. Errors up to 23% in v(e) and 28% in K-trans were found for the normal simulations, and 67% in v(e) and 61% in K-trans for the impaired simulations. If this bi-exponential curve is used as an input function to the generalized kinetic model and used in oncology, estimates of tissue permeability and leakage volume will possess large errors due to variation in C-p(t) curves between subjects.

AB - Dynamic contrast enhanced MRI (DCE-MRI) and pharmacokinetic models have been used to measure tumour permeability (K-trans) and leakage volume (v(e)) in numerous studies. The construction of pharmacokinetic models describing such tissue properties relies on defining the blood plasma concentration of contrast agent with respect to time (C-p(t)). When direct measurement is not possible a bi-exponential decay has been applied using data from healthy volunteers. This work investigates, by simulation, the magnitude of errors resulting from this definition with respect to normal variation in renal function and for cases with renal impairment. Errors up to 23% in v(e) and 28% in K-trans were found for the normal simulations, and 67% in v(e) and 61% in K-trans for the impaired simulations. If this bi-exponential curve is used as an input function to the generalized kinetic model and used in oncology, estimates of tissue permeability and leakage volume will possess large errors due to variation in C-p(t) curves between subjects.

KW - BRAIN-BARRIER PERMEABILITY

KW - CONTRAST AGENT UPTAKE

KW - GD-DTPA ENHANCEMENT

KW - TRACER KINETICS

KW - DYNAMIC MRI

KW - PARAMETERS

KW - MODEL

KW - PHARMACOKINETICS

KW - INJECTION

KW - CONSTANT

U2 - 10.1088/0031-9155/49/10/014

DO - 10.1088/0031-9155/49/10/014

M3 - Article

VL - 49

SP - 2041

EP - 2051

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 10

ER -