The efficacy of “disease/no disease” grading for diabetic retinopathy in a systematic screening programme

S Philip, A D Fleming, K A Goatman, S Fonseca, P McNamee, G S Scotland, G J Prescott, P F Sharp, J. A. Olson

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Aim: To assess the efficacy of automated “disease/no disease” grading for diabetic retinopathy within a systematic screening programme.
Methods: Anonymised images were obtained from consecutive patients attending a regional primary care based diabetic retinopathy screening programme. A training set of 1067 images was used to develop automated grading algorithms. The final software was tested using a separate set of 14406 images from 6722 patients. The sensitivity and specificity of manual and automated systems operating as “disease/no disease” graders (detecting poor quality images and any diabetic retinopathy) were determined relative to a clinical reference standard.
Results: The reference standard classified 8.2% of the patients as having ungradable images (technical failures) and 62.5% as having no retinopathy. Detection of technical failures or any retinopathy was achieved by manual grading with 86.5% sensitivity (95% confidence interval 85.1 to 87.8) and 95.3% specificity (94.6 to 95.9) and by automated grading with 90.5% sensitivity (89.3 to 91.6) and 67.4% specificity (66.0 to 68.8). Manual and automated grading detected 99.1% and 97.9%, respectively, of patients with referable or observable retinopathy/maculopathy. Manual and automated grading detected 95.7% and 99.8%, respectively, of technical failures.
Conclusion: Automated “disease/no disease” grading of diabetic retinopathy could safely reduce the burden of grading in diabetic retinopathy screening programmes.
Original languageEnglish
Pages (from-to)1512-1517
Number of pages6
JournalBritish Journal of Ophthalmology
Volume91
Issue number11
Early online date15 May 2007
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Aged
  • Aged, 80 and over
  • Algorithms
  • Diabetic Retinopathy
  • Female
  • Humans
  • Male
  • Mass Screening
  • Middle Aged
  • Program Evaluation
  • Sensitivity and Specificity
  • Severity of Illness Index

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