Abstract
Nitric oxide (NO) is a modulator of left ventricular hypertrophy (LVH) and myocardial relaxation. The impact of NO availability on development of LVH has never been demonstrated in humans. We tested the hypotheses that elevation of asymmetric dimethylarginine (ADMA) concentrations (biochemical marker of decreased NO generation), and impairment of vascular responsiveness to NO donor GTN, would each predict the presence of LVH and associated LV diastolic dysfunction in a normal aging population.
Original language | English |
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Pages (from-to) | 41-46 |
Number of pages | 6 |
Journal | Nitric Oxide: Biology and Chemistry |
Volume | 25 |
Issue number | 1 |
DOIs | |
Publication status | Published - 30 Jun 2011 |
Keywords
- left ventricular mass
- nitric oxide
- vascular function
- diastolic function
- asymmetric dimethylarginine