Abstract
Original language | English |
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Pages (from-to) | 41-46 |
Number of pages | 6 |
Journal | Nitric Oxide: Biology and Chemistry |
Volume | 25 |
Issue number | 1 |
DOIs | |
Publication status | Published - 30 Jun 2011 |
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Keywords
- left ventricular mass
- nitric oxide
- vascular function
- diastolic function
- asymmetric dimethylarginine
Cite this
The endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) predicts LV mass independent of afterload. / Sverdlov, A L; Ngo, D T M; Nightingale, A K; Rajendran, S; Mishra, K; Heresztyn, T; Ritchie, R H; Marwick, T H; Frenneaux, M P; Horowitz, J D.
In: Nitric Oxide: Biology and Chemistry, Vol. 25, No. 1, 30.06.2011, p. 41-46.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) predicts LV mass independent of afterload
AU - Sverdlov, A L
AU - Ngo, D T M
AU - Nightingale, A K
AU - Rajendran, S
AU - Mishra, K
AU - Heresztyn, T
AU - Ritchie, R H
AU - Marwick, T H
AU - Frenneaux, M P
AU - Horowitz, J D
N1 - Copyright © 2011. Published by Elsevier Inc.
PY - 2011/6/30
Y1 - 2011/6/30
N2 - Nitric oxide (NO) is a modulator of left ventricular hypertrophy (LVH) and myocardial relaxation. The impact of NO availability on development of LVH has never been demonstrated in humans. We tested the hypotheses that elevation of asymmetric dimethylarginine (ADMA) concentrations (biochemical marker of decreased NO generation), and impairment of vascular responsiveness to NO donor GTN, would each predict the presence of LVH and associated LV diastolic dysfunction in a normal aging population.
AB - Nitric oxide (NO) is a modulator of left ventricular hypertrophy (LVH) and myocardial relaxation. The impact of NO availability on development of LVH has never been demonstrated in humans. We tested the hypotheses that elevation of asymmetric dimethylarginine (ADMA) concentrations (biochemical marker of decreased NO generation), and impairment of vascular responsiveness to NO donor GTN, would each predict the presence of LVH and associated LV diastolic dysfunction in a normal aging population.
KW - left ventricular mass
KW - nitric oxide
KW - vascular function
KW - diastolic function
KW - asymmetric dimethylarginine
U2 - 10.1016/j.niox.2011.04.009
DO - 10.1016/j.niox.2011.04.009
M3 - Article
VL - 25
SP - 41
EP - 46
JO - Nitric Oxide: Biology and Chemistry
JF - Nitric Oxide: Biology and Chemistry
SN - 1089-8603
IS - 1
ER -