The Epidemiology of infertility in the North East of Scotland.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

BACKGROUND There is a perception that the prevalence of infertility is on the rise. This study aimed to determine the current prevalence of infertility in a defined geographical population, ascertain changes in self-reported infertility over time and identify risk factors associated with infertility. METHODS A postal questionnaire survey of a random population-based sample of women aged 31–50 years was performed in the Grampian region of Scotland. Questions addressed the following areas: pregnancy history, length of time taken to become pregnant each time, whether medical advice had been sought and self-reported exposure to factors associated with infertility. RESULTS Among 4466 women who responded, 400 (9.0%) [95% CI 8.1, 9.8] had chosen not to have children. Of the remaining 4066 women, 3283 (80.7%) [95% CI 79.5, 82.0] reported no difficulties in having children and the remaining 783 (19.3%) [95% CI 18.1, 20.5] had experienced infertility, defined as having difficulty in becoming pregnant for more than 12 months and/or seeking medical advice. In total 398 (9.8%) [95% CI 8.9, 10.7] women had primary infertility, 285 (7.0%) [95% CI 6.2, 7.8] had secondary infertility, 100 (2.5%) [95% CI 2.0, 2.9] had primary as well as secondary infertility. A total of 342 (68.7%) and 208 (73.0%) women with primary and secondary infertility, respectively, sought medical advice and 202 (59.1%) and 118 (56.7%) women in each group subsequently conceived. History of pelvic surgery, Chlamydial infection, endometriosis, chemotherapy, long-term health problems and obesity were associated with infertility. In comparison with a similar survey of women aged 46–50 from the same geographical area, the prevalence of both primary infertility (>24 months) [70/1081, (6.5%) versus 68/710 (9.6%) P = 0.02] and secondary infertility [29/1081 (2.7%) versus 40/710 (5.6%) P = 0.002] were significantly lower. CONCLUSIONS Nearly one in five women attempting conception sampled in this study experienced infertility, although over half of them eventually conceived. Fertility problems were associated with endometriosis, Chlamydia trachomatis infection and pelvic surgery, as well as obesity, chemotherapy and some long-term chronic medical conditions. There is no evidence of an increase in the prevalence of infertility in this population over the past 20 years.
Original languageEnglish
Pages (from-to)3096-3107
Number of pages12
JournalHuman Reproduction
Volume24
Issue number12
Early online date14 Aug 2009
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Scotland
Infertility
Epidemiology
Endometriosis
Obesity
Population
Drug Therapy
Reproductive History
Chlamydia Infections
Chlamydia trachomatis
Fertility

Keywords

  • prevalence
  • risk factors
  • subfertility
  • epidemiology
  • infertility

Cite this

The Epidemiology of infertility in the North East of Scotland. / Bhattacharya, Siladitya; Porter, Maureen; Raja, Edwin Amalraj; Templeton, Allan; Hamilton, M; Lee, Amanda Jane; Kurinczuk, J.

In: Human Reproduction, Vol. 24, No. 12, 12.2009, p. 3096-3107.

Research output: Contribution to journalArticle

@article{7414be559bf0483792a02a7a89775477,
title = "The Epidemiology of infertility in the North East of Scotland.",
abstract = "BACKGROUND There is a perception that the prevalence of infertility is on the rise. This study aimed to determine the current prevalence of infertility in a defined geographical population, ascertain changes in self-reported infertility over time and identify risk factors associated with infertility. METHODS A postal questionnaire survey of a random population-based sample of women aged 31–50 years was performed in the Grampian region of Scotland. Questions addressed the following areas: pregnancy history, length of time taken to become pregnant each time, whether medical advice had been sought and self-reported exposure to factors associated with infertility. RESULTS Among 4466 women who responded, 400 (9.0{\%}) [95{\%} CI 8.1, 9.8] had chosen not to have children. Of the remaining 4066 women, 3283 (80.7{\%}) [95{\%} CI 79.5, 82.0] reported no difficulties in having children and the remaining 783 (19.3{\%}) [95{\%} CI 18.1, 20.5] had experienced infertility, defined as having difficulty in becoming pregnant for more than 12 months and/or seeking medical advice. In total 398 (9.8{\%}) [95{\%} CI 8.9, 10.7] women had primary infertility, 285 (7.0{\%}) [95{\%} CI 6.2, 7.8] had secondary infertility, 100 (2.5{\%}) [95{\%} CI 2.0, 2.9] had primary as well as secondary infertility. A total of 342 (68.7{\%}) and 208 (73.0{\%}) women with primary and secondary infertility, respectively, sought medical advice and 202 (59.1{\%}) and 118 (56.7{\%}) women in each group subsequently conceived. History of pelvic surgery, Chlamydial infection, endometriosis, chemotherapy, long-term health problems and obesity were associated with infertility. In comparison with a similar survey of women aged 46–50 from the same geographical area, the prevalence of both primary infertility (>24 months) [70/1081, (6.5{\%}) versus 68/710 (9.6{\%}) P = 0.02] and secondary infertility [29/1081 (2.7{\%}) versus 40/710 (5.6{\%}) P = 0.002] were significantly lower. CONCLUSIONS Nearly one in five women attempting conception sampled in this study experienced infertility, although over half of them eventually conceived. Fertility problems were associated with endometriosis, Chlamydia trachomatis infection and pelvic surgery, as well as obesity, chemotherapy and some long-term chronic medical conditions. There is no evidence of an increase in the prevalence of infertility in this population over the past 20 years.",
keywords = "prevalence, risk factors, subfertility , epidemiology, infertility",
author = "Siladitya Bhattacharya and Maureen Porter and Raja, {Edwin Amalraj} and Allan Templeton and M Hamilton and Lee, {Amanda Jane} and J Kurinczuk",
year = "2009",
month = "12",
doi = "10.1093/humrep/dep287",
language = "English",
volume = "24",
pages = "3096--3107",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "OXFORD UNIV PRESS",
number = "12",

}

TY - JOUR

T1 - The Epidemiology of infertility in the North East of Scotland.

AU - Bhattacharya, Siladitya

AU - Porter, Maureen

AU - Raja, Edwin Amalraj

AU - Templeton, Allan

AU - Hamilton, M

AU - Lee, Amanda Jane

AU - Kurinczuk, J

PY - 2009/12

Y1 - 2009/12

N2 - BACKGROUND There is a perception that the prevalence of infertility is on the rise. This study aimed to determine the current prevalence of infertility in a defined geographical population, ascertain changes in self-reported infertility over time and identify risk factors associated with infertility. METHODS A postal questionnaire survey of a random population-based sample of women aged 31–50 years was performed in the Grampian region of Scotland. Questions addressed the following areas: pregnancy history, length of time taken to become pregnant each time, whether medical advice had been sought and self-reported exposure to factors associated with infertility. RESULTS Among 4466 women who responded, 400 (9.0%) [95% CI 8.1, 9.8] had chosen not to have children. Of the remaining 4066 women, 3283 (80.7%) [95% CI 79.5, 82.0] reported no difficulties in having children and the remaining 783 (19.3%) [95% CI 18.1, 20.5] had experienced infertility, defined as having difficulty in becoming pregnant for more than 12 months and/or seeking medical advice. In total 398 (9.8%) [95% CI 8.9, 10.7] women had primary infertility, 285 (7.0%) [95% CI 6.2, 7.8] had secondary infertility, 100 (2.5%) [95% CI 2.0, 2.9] had primary as well as secondary infertility. A total of 342 (68.7%) and 208 (73.0%) women with primary and secondary infertility, respectively, sought medical advice and 202 (59.1%) and 118 (56.7%) women in each group subsequently conceived. History of pelvic surgery, Chlamydial infection, endometriosis, chemotherapy, long-term health problems and obesity were associated with infertility. In comparison with a similar survey of women aged 46–50 from the same geographical area, the prevalence of both primary infertility (>24 months) [70/1081, (6.5%) versus 68/710 (9.6%) P = 0.02] and secondary infertility [29/1081 (2.7%) versus 40/710 (5.6%) P = 0.002] were significantly lower. CONCLUSIONS Nearly one in five women attempting conception sampled in this study experienced infertility, although over half of them eventually conceived. Fertility problems were associated with endometriosis, Chlamydia trachomatis infection and pelvic surgery, as well as obesity, chemotherapy and some long-term chronic medical conditions. There is no evidence of an increase in the prevalence of infertility in this population over the past 20 years.

AB - BACKGROUND There is a perception that the prevalence of infertility is on the rise. This study aimed to determine the current prevalence of infertility in a defined geographical population, ascertain changes in self-reported infertility over time and identify risk factors associated with infertility. METHODS A postal questionnaire survey of a random population-based sample of women aged 31–50 years was performed in the Grampian region of Scotland. Questions addressed the following areas: pregnancy history, length of time taken to become pregnant each time, whether medical advice had been sought and self-reported exposure to factors associated with infertility. RESULTS Among 4466 women who responded, 400 (9.0%) [95% CI 8.1, 9.8] had chosen not to have children. Of the remaining 4066 women, 3283 (80.7%) [95% CI 79.5, 82.0] reported no difficulties in having children and the remaining 783 (19.3%) [95% CI 18.1, 20.5] had experienced infertility, defined as having difficulty in becoming pregnant for more than 12 months and/or seeking medical advice. In total 398 (9.8%) [95% CI 8.9, 10.7] women had primary infertility, 285 (7.0%) [95% CI 6.2, 7.8] had secondary infertility, 100 (2.5%) [95% CI 2.0, 2.9] had primary as well as secondary infertility. A total of 342 (68.7%) and 208 (73.0%) women with primary and secondary infertility, respectively, sought medical advice and 202 (59.1%) and 118 (56.7%) women in each group subsequently conceived. History of pelvic surgery, Chlamydial infection, endometriosis, chemotherapy, long-term health problems and obesity were associated with infertility. In comparison with a similar survey of women aged 46–50 from the same geographical area, the prevalence of both primary infertility (>24 months) [70/1081, (6.5%) versus 68/710 (9.6%) P = 0.02] and secondary infertility [29/1081 (2.7%) versus 40/710 (5.6%) P = 0.002] were significantly lower. CONCLUSIONS Nearly one in five women attempting conception sampled in this study experienced infertility, although over half of them eventually conceived. Fertility problems were associated with endometriosis, Chlamydia trachomatis infection and pelvic surgery, as well as obesity, chemotherapy and some long-term chronic medical conditions. There is no evidence of an increase in the prevalence of infertility in this population over the past 20 years.

KW - prevalence

KW - risk factors

KW - subfertility

KW - epidemiology

KW - infertility

U2 - 10.1093/humrep/dep287

DO - 10.1093/humrep/dep287

M3 - Article

VL - 24

SP - 3096

EP - 3107

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 12

ER -